{"doi":"10.1101/2023.06.12.544691","title":"Microglial P2Y <sub>6</sub> calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis","abstract":"SUMMARY Microglial calcium signaling is rare in a baseline state but shows strong engagement during early epilepsy development. The mechanism and purpose behind microglial calcium signaling is not known. By developing an in vivo UDP fluorescent sensor, GRAB UDP1.0 , we discovered that UDP release is a conserved response to seizures and excitotoxicity across brain regions. UDP signals to the microglial P2Y 6 receptor for broad increases in calcium signaling during epileptogenesis. UDP-P2Y 6 signaling is necessary for lysosome upregulation across limbic brain regions and enhances production of pro-inflammatory cytokines—TNFα and IL-1β. Failures in lysosome upregulation, observed in P2Y 6 KO mice, can also be phenocopied by attenuating microglial calcium signaling in Calcium Extruder (“CalEx”) mice. In the hippocampus, only microglia with P2Y 6 expression can perform full neuronal engulfment, which substantially reduces CA3 neuron survival and impairs cognition. Our results demonstrate that calcium activity, driven by UDP-P2Y 6 signaling, is a signature of phagocytic and pro-inflammatory function in microglia during epileptogenesis.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":390262,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1161562,"name":"Bohan Li","orcid":"0000-0001-9388-7226","position":1,"is_corresponding":false},{"id":256583,"name":"Katayoun Ayasoufi","orcid":"0000-0002-3797-0823","position":2,"is_corresponding":false},{"id":689266,"name":"Shunyi Zhao","orcid":"0000-0001-7265-0801","position":3,"is_corresponding":false},{"id":556049,"name":"Manling Xie","orcid":"0000-0002-1747-1699","position":4,"is_corresponding":false},{"id":1162047,"name":"Grace Thyen","orcid":null,"position":5,"is_corresponding":false},{"id":1147431,"name":"Benjamin Hur","orcid":null,"position":6,"is_corresponding":false},{"id":255100,"name":"Jiaying Zheng","orcid":"0000-0002-7457-6198","position":7,"is_corresponding":false},{"id":991136,"name":"Yue Liang","orcid":"0000-0002-5925-6743","position":8,"is_corresponding":false},{"id":493389,"name":"Zhaofa Wu","orcid":"0000-0003-2027-5194","position":9,"is_corresponding":false},{"id":233468,"name":"Xinzhu Yu","orcid":"0000-0003-1244-0110","position":10,"is_corresponding":false},{"id":252213,"name":"Jaeyun Sung","orcid":"0000-0002-3005-2798","position":11,"is_corresponding":false},{"id":256585,"name":"Aaron J. Johnson","orcid":"0000-0002-7921-484X","position":12,"is_corresponding":false},{"id":151125,"name":"Yulong Li","orcid":"0000-0002-9166-9919","position":13,"is_corresponding":false},{"id":258025,"name":"Long‐Jun Wu","orcid":"0000-0001-8019-3380","position":14,"is_corresponding":false},{"id":559377,"name":"Anthony D. Umpierre","orcid":"0000-0002-1470-8881","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:18:32.854511Z","pmid":"37398001","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}