{"doi":"10.1101/2023.06.08.544257","title":"Not everything, not everywhere, not all at once: a study of brain-wide encoding of movement","abstract":"Activity related to movement is found throughout sensory and motor regions of the brain. However, it remains unclear how movement-related activity is distributed across the brain and whether systematic differences exist between brain areas. Here, we analyzed movement related activity in brain-wide recordings containing more than 50,000 neurons in mice performing a decision-making task. Using multiple techniques, from markers to deep neural networks, we find that movement-related signals were pervasive across the brain, but systematically differed across areas. Movement-related activity was stronger in areas closer to the motor or sensory periphery. Delineating activity in terms of sensory- and motor-related components revealed finer scale structures of their encodings within brain areas. We further identified activity modulation that correlates with decision-making and uninstructed movement. Our work charts out a largescale map of movement encoding and provides a roadmap for dissecting different forms of movement and decision-making related encoding across multi-regional neural circuits.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":389509,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7271,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":559027,"name":"Susu Chen","orcid":"0000-0002-5065-1157","position":1,"is_corresponding":false},{"id":1159893,"name":"Yi Liu","orcid":"0009-0008-5899-3662","position":2,"is_corresponding":false},{"id":1160683,"name":"Dave Liu","orcid":null,"position":3,"is_corresponding":false},{"id":250506,"name":"Karel Svoboda","orcid":"0000-0002-6670-7362","position":4,"is_corresponding":false},{"id":336700,"name":"Nuo Li","orcid":"0000-0002-6613-5018","position":5,"is_corresponding":false},{"id":495611,"name":"Shaul Druckmann","orcid":"0000-0003-0068-3377","position":6,"is_corresponding":false},{"id":724589,"name":"Ziyue Wang","orcid":"0000-0003-2662-3946","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:18:27.054415Z","pmid":"37333216","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}