{"doi":"10.1101/2023.06.02.543490","title":"Dendritic excitations govern back-propagation via a spike-rate accelerometer","abstract":"Summary Dendrites on neurons support nonlinear electrical excitations, but the computational significance of these events is not well understood. We developed molecular, optical, and analytical tools to map sub-millisecond voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons under diverse optogenetic and synaptic stimulus patterns, in acute brain slices. We observed history-dependent spike back-propagation in distal dendrites, driven by locally generated Na + spikes (dSpikes). Dendritic depolarization created a transient window for dSpike propagation, opened by A-type K V channel inactivation, and closed by slow Na V inactivation. Collisions of dSpikes with synaptic inputs triggered calcium channel and N-methyl-D-aspartate receptor (NMDAR)-dependent plateau potentials, with accompanying complex spikes at the soma. This hierarchical ion channel network acts as a spike-rate accelerometer, providing an intuitive picture of how dendritic excitations shape associative plasticity rules.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":390149,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1161950,"name":"David Wong-Campos","orcid":null,"position":1,"is_corresponding":false},{"id":1161092,"name":"Daniel G. Itkis","orcid":"0009-0003-8948-2260","position":2,"is_corresponding":false},{"id":1161445,"name":"Byung Hun Lee","orcid":"0000-0002-0001-4846","position":3,"is_corresponding":false},{"id":807437,"name":"Yitong Qi","orcid":null,"position":4,"is_corresponding":false},{"id":806835,"name":"Hunter C. Davis","orcid":"0000-0003-1655-692X","position":5,"is_corresponding":false},{"id":984339,"name":"Benjamin Antin","orcid":"0000-0002-3361-985X","position":6,"is_corresponding":false},{"id":1161446,"name":"Amol Pasarkar","orcid":"0000-0002-2970-3207","position":7,"is_corresponding":false},{"id":259888,"name":"Jonathan B. Grimm","orcid":"0000-0003-0331-4200","position":8,"is_corresponding":false},{"id":1161725,"name":"Sarah E. Plutkis","orcid":null,"position":9,"is_corresponding":false},{"id":1069745,"name":"Katie L. Holland","orcid":"0009-0007-1183-195X","position":10,"is_corresponding":false},{"id":233157,"name":"Liam Paninski","orcid":"0000-0002-0276-7032","position":11,"is_corresponding":false},{"id":249822,"name":"Luke D. Lavis","orcid":"0000-0002-0789-6343","position":12,"is_corresponding":false},{"id":253698,"name":"Adam E. Cohen","orcid":"0000-0002-8699-2404","position":13,"is_corresponding":false},{"id":806838,"name":"Pojeong Park","orcid":"0000-0002-5574-6104","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:18:32.854511Z","pmid":"37398232","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}