{"doi":"10.1101/2023.05.26.23290467","title":"Self-Directed Home-Based Dim-Light Melatonin Onset Collection: The Circadia Pilot Study","abstract":"Abstract Study Objectives To test the feasibility of a novel at-home salivary Dim Light Melatonin Onset (DLMO) assessment protocol to measure the endogenous circadian phase of 10 individuals (1 Advanced Sleep-Wake Phase Disorder patient (ASWPD), 4 Delayed Sleep-Wake Phase Disorder patients (DSWPD), and 5 controls). Methods The study involved 10 participants (sex at birth: females = 9; male= 1), who ranged between 27 to 63 years old, with an average age of 38 years old. Our study population consisted of 7 individuals who identified as white and 3 who identified as Asian. Our participants were diverse in gender identity (woman = 7, male = 1, transgender = 1, nonbinary = 1, none = 1) .The study tracked the sleep and activity patterns of 10 individuals over a 5-6 week period using self-reported online sleep diaries and objective actigraphy data. Participants completed two self-directed DLMO assessments, approximately one week apart, adhering to objective compliance measures. Participants completed the study entirely remotely: they completed all sleep diaries and other evaluations online and were mailed a kit with all materials needed to perform the actigraphy and at-home sample collections. Results Salivary DLMO times were calculated for 8/10 participants using the Hockeystick method. DLMO times were on average 3 hours and 18 minutes earlier than self-reported sleep onset times (DSPD: 12:04 AM, controls: 9:55 PM.) Among the 6 participants for whom we calculated two separate DLMO times, DLMOs 1 and 2 were 96% correlated (p<0.0005.) Conclusions Our results indicate that self-directed, at-home DLMO assessments are feasible and accurate. The current protocol may serve as a framework to reliably assess circadian phase in both clinical and general populations.","journal":"medRxiv","year":2023,"id":393314,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8907,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1045468,"name":"Jessica Love","orcid":"0009-0007-9923-1181","position":1,"is_corresponding":false},{"id":270289,"name":"Oluwaseun Akeju","orcid":"0000-0002-6740-1250","position":2,"is_corresponding":false},{"id":1167147,"name":"J. C. Cherry","orcid":"0009-0002-4589-4696","position":3,"is_corresponding":false},{"id":1167148,"name":"Lovemore Kunorozva","orcid":"0000-0003-4262-6696","position":4,"is_corresponding":false},{"id":1135044,"name":"Salim Qadri","orcid":"0000-0003-2972-1197","position":5,"is_corresponding":false},{"id":342319,"name":"Shadab A. Rahman","orcid":"0000-0002-8729-0500","position":6,"is_corresponding":false},{"id":280809,"name":"M. Brandon Westover","orcid":"0000-0003-4803-312X","position":7,"is_corresponding":false},{"id":923859,"name":"John W. Winkelman","orcid":"0000-0003-1673-5418","position":8,"is_corresponding":false},{"id":525138,"name":"Jacqueline M. Lane","orcid":"0000-0001-6101-2855","position":9,"is_corresponding":false},{"id":1167390,"name":"Gregory Bormes","orcid":null,"position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T01:19:01.355412Z","pmid":"37398260","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}