{"doi":"10.1101/2023.05.24.23290358","title":"Trends in Prevalence of Cannabis Use Disorders among U.S. Veterans with and without Psychiatric Disorders Between 2005 and 2019","abstract":"<jats:title>ABSTRACT</jats:title>\n                <jats:sec>\n                  <jats:title>Objective</jats:title>\n                  <jats:p>Cannabis use disorders (CUD) are increasing among U.S. adults and are more prevalent among cannabis users with comorbid psychiatric disorders. Changing cannabis laws, increasing cannabis availability, and higher potency cannabis may have recently placed cannabis users with psychiatric disorders at disproportionately increasing risk for CUD. The authors used Veterans Health Administration (VHA) data to examine whether trends in CUD prevalence among VHA patients differ by whether they have psychiatric disorders.</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>VHA electronic health records from 2005 to 2019 (n range=4,332,165-5,657,277) were used to identify overall and age-specific (&lt;35, 35-64, ≥65 years) trends in prevalence of CUD diagnoses among patients with depressive, anxiety, PTSD, bipolar, or psychotic-spectrum disorders, and to compare these to corresponding trends among patients without any of these disorders. Given transitions in ICD coding, differences in trends were tested within two periods: 2005–2014 (ICD-9-CM) and 2016–2019 (ICD-10-CM).</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>Greater increases in prevalence of CUD diagnoses were observed in veterans with, compared to without, psychiatric disorders (2005-2014: difference in prevalence change=1.91%, 95% CI=1.87%-1.96%; 2016-2019: 0.34%, 95% CI=0.29%-0.38%). Disproportionate increases in CUD prevalence among those with psychiatric disorders were greatest in veterans ages &lt;35 between 2005-2014, and in those ages ≥65 between 2016-2019. Among patients with psychiatric disorders, greatest increases in CUD prevalences were observed in those with bipolar and psychotic-spectrum disorders.</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Results highlight disproportionately increasing disparities in risk of CUD among VA patients with common psychiatric disorders. Greater public health and clinical efforts are needed to monitor, prevent and treat CUD among this population.</jats:p>\n                </jats:sec>","journal":null,"year":null,"id":671608,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1143039,"name":"Carol A. Malte","orcid":"0000-0002-6126-0733","position":1,"is_corresponding":false},{"id":262362,"name":"Mark Olfson","orcid":"0000-0002-3958-5662","position":2,"is_corresponding":false},{"id":302340,"name":"Melanie M. Wall","orcid":"0000-0001-6673-3467","position":3,"is_corresponding":false},{"id":292820,"name":"Katherine M. Keyes","orcid":"0000-0002-5624-021X","position":4,"is_corresponding":false},{"id":431034,"name":"Charles Maynard","orcid":"0000-0002-1644-7814","position":5,"is_corresponding":false},{"id":525332,"name":"Jaimie L. Gradus","orcid":"0000-0003-1459-5327","position":6,"is_corresponding":false},{"id":315655,"name":"Andrew J. Saxon","orcid":"0000-0003-3880-2589","position":7,"is_corresponding":false},{"id":1754614,"name":"Silvia S. Martins","orcid":null,"position":8,"is_corresponding":false},{"id":268900,"name":"Salomeh Keyhani","orcid":"0000-0001-9124-9618","position":9,"is_corresponding":false},{"id":1754615,"name":"Yoanna McDowell","orcid":null,"position":10,"is_corresponding":false},{"id":304343,"name":"David S. Fink","orcid":"0000-0003-1531-1525","position":11,"is_corresponding":false},{"id":380842,"name":"Zachary L. Mannes","orcid":"0000-0002-0357-6051","position":12,"is_corresponding":false},{"id":660072,"name":"Sarah Gutkind","orcid":"0000-0002-9489-7597","position":13,"is_corresponding":false},{"id":388686,"name":"Deborah S. Hasin","orcid":"0000-0002-6533-7021","position":14,"is_corresponding":false},{"id":686700,"name":"Ofir Livne","orcid":"0000-0001-6673-0231","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Trends in Prevalence of Cannabis Use Disorders among U.S. Veterans with and without Psychiatric Disorders Between 2005 and 2019","abstract":"<jats:title>ABSTRACT</jats:title>\n                <jats:sec>\n                  <jats:title>Objective</jats:title>\n                  <jats:p>Cannabis use disorders (CUD) are increasing among U.S. adults and are more prevalent among cannabis users with comorbid psychiatric disorders. Changing cannabis laws, increasing cannabis availability, and higher potency cannabis may have recently placed cannabis users with psychiatric disorders at disproportionately increasing risk for CUD. The authors used Veterans Health Administration (VHA) data to examine whether trends in CUD prevalence among VHA patients differ by whether they have psychiatric disorders.</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>VHA electronic health records from 2005 to 2019 (n range=4,332,165-5,657,277) were used to identify overall and age-specific (&lt;35, 35-64, ≥65 years) trends in prevalence of CUD diagnoses among patients with depressive, anxiety, PTSD, bipolar, or psychotic-spectrum disorders, and to compare these to corresponding trends among patients without any of these disorders. Given transitions in ICD coding, differences in trends were tested within two periods: 2005–2014 (ICD-9-CM) and 2016–2019 (ICD-10-CM).</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>Greater increases in prevalence of CUD diagnoses were observed in veterans with, compared to without, psychiatric disorders (2005-2014: difference in prevalence change=1.91%, 95% CI=1.87%-1.96%; 2016-2019: 0.34%, 95% CI=0.29%-0.38%). Disproportionate increases in CUD prevalence among those with psychiatric disorders were greatest in veterans ages &lt;35 between 2005-2014, and in those ages ≥65 between 2016-2019. Among patients with psychiatric disorders, greatest increases in CUD prevalences were observed in those with bipolar and psychotic-spectrum disorders.</jats:p>\n                </jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Results highlight disproportionately increasing disparities in risk of CUD among VA patients with common psychiatric disorders. Greater public health and clinical efforts are needed to monitor, prevent and treat CUD among this population.</jats:p>\n                </jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19162232","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"5K23DA057417-02","title":"Cannabis use patterns and associations with cognitive impairment in older adults"},{"funder_name":"National Institutes of Health","grant_id":"3R01DA048860-02S1","title":"Impact of Medical and Recreational Marijuana Laws on Cannabis, Opioids and Psychiatric Medications:  National Study of VA Patients, 2000 -2024"}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.medrxiv.org/content/medrxiv/early/2023/05/28/2023.05.24.23290358.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2023.05.24.23290358","host_type":"publisher"},{"url":"https://doi.org/10.1101/2023.05.24.23290358","host_type":""},{"url":"https://doi.org/10.1176/appi.ajp.20230168","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/38018141","host_type":""},{"url":"https://escholarship.org/uc/item/77z35632","host_type":""},{"url":"https://doi.org/https://doi.org/10.1176/appi.ajp.20230168","host_type":""}],"fields_of_study":["03 medical and health sciences","0305 other medical science"],"mesh_terms":[],"keywords":["Adult","Marijuana Abuse","Psychotic Disorders","Epidemiology","Substance-Related and Addictive Disorders","Substance-Related Disorders","Prevalence","Humans","Aged","Veterans","Cannabis"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T03:31:32.148471Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}