{"doi":"10.1101/2023.05.04.539430","title":"Dimensional clinical phenotyping using post-mortem brain donor medical records: Association with neuropathology","abstract":"INTRODUCTION: Transdiagnostic dimensional phenotypes are essential to investigate the relationship between continuous symptom dimensions and pathological changes. This is a fundamental challenge to postmortem work, as assessment of newly developed phenotypic concepts needs to rely on existing records. METHODS: We adapted well-validated methodologies to compute NIMH research domain criteria (RDoC) scores using natural language processing (NLP) from electronic health records (EHRs) obtained from post-mortem brain donors and tested whether RDoC cognitive domain scores were associated with hallmark Alzheimer's disease (AD) neuropathological measures. RESULTS: Our results confirm an association of EHR-derived cognitive scores with hallmark neuropathological findings. Notably, higher neuropathological load, particularly neuritic plaques, was associated with higher cognitive burden scores in the frontal (ß=0.38, p=0.0004), parietal (ß=0.35, p=0.0008), temporal (ß=0.37, p=0. 0004) and occipital (ß=0.37, p=0.0003) lobes. DISCUSSION: This proof of concept study supports the validity of NLP-based methodologies to obtain quantitative measures of RDoC clinical domains from postmortem EHR.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":396339,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5797,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1147138,"name":"Shu Dan","orcid":null,"position":1,"is_corresponding":false},{"id":1147139,"name":"Anna P. Lally","orcid":null,"position":2,"is_corresponding":false},{"id":1147140,"name":"Michael Chatigny","orcid":null,"position":3,"is_corresponding":false},{"id":1147141,"name":"Sangeetha Vempati","orcid":null,"position":4,"is_corresponding":false},{"id":1147142,"name":"Joshua Abston","orcid":null,"position":5,"is_corresponding":false},{"id":952335,"name":"Peter Durning","orcid":"0000-0001-8350-8587","position":6,"is_corresponding":false},{"id":412334,"name":"Derek H. Oakley","orcid":"0000-0002-6998-9510","position":7,"is_corresponding":false},{"id":808901,"name":"Thomas H. McCoy","orcid":"0000-0002-5624-0439","position":8,"is_corresponding":false},{"id":35434,"name":"Torsten Klengel","orcid":"0000-0001-7045-9229","position":9,"is_corresponding":false},{"id":6264,"name":"Sabina Berretta","orcid":"0000-0002-4057-7766","position":10,"is_corresponding":false},{"id":821814,"name":"Jonathan Vogelgsang","orcid":"0000-0001-9326-8193","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T01:19:31.472087Z","pmid":"37205494","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}