{"doi":"10.1101/2023.04.27.23289207","title":"Dengue in Cambodia 2002-2020: Cases, Characteristics and Capture by National Surveillance","abstract":"Objective: Data from 19 years of national dengue surveillance in Cambodia (2002-2020) were analyzed to describe trends in dengue case characteristics and incidence. Methods: Generalized additive models were fitted to dengue case incidence and characteristics (mean age, case phenotype, fatality) over time. Dengue incidence in a pediatric cohort study (2018-2020) was compared to national data during the same period to evaluate disease under-estimation by national surveillance. Findings: During 2002-2020, there were 353,270 cases of dengue (average age-adjusted incidence 1.75 cases/1,000 persons/year) recorded in Cambodia, with an estimated 2.1-fold increase in case incidence between 2002 and 2020 (slope = 0.0058, SE = 0.0021, p = 0.006). Mean age of infected individuals increased from 5.8 years in 2002 to 9.1 years in 2020 (slope = 0.18, SE = 0.088, p <0.001); case fatality rates decreased from 1.77% in 2002 to 0.10% in 2020 (slope = -0.16, SE = 0.0050, p <0.001). When compared to cohort data, national data under-estimated clinically apparent dengue case incidence by 5.0-fold (95% CI 0.2 - 26.5), and overall dengue case incidence (both apparent and inapparent cases) by 33.6-fold (range: 18.7- 53.6). Conclusion: Dengue incidence in Cambodia is increasing and disease is shifting to older pediatric populations. National surveillance continues to under-estimate case numbers. Future interventions should account for disease under-estimation and shifting demographics for scaling and to target appropriate age groups.","journal":"medRxiv","year":2023,"id":393219,"datarank":0.30151845841764513,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.060102771552530056,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.060102771552530056,"corpus_percentile":45.13808308192156,"corpus_rank":7093,"citation_count":4,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8395,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1167082,"name":"Yimei Li","orcid":"0000-0003-0774-4515","position":1,"is_corresponding":false},{"id":868604,"name":"Andrea R. Pacheco","orcid":"0000-0001-8705-5343","position":2,"is_corresponding":false},{"id":290868,"name":"Chanthap Lon","orcid":"0000-0003-4901-5003","position":3,"is_corresponding":false},{"id":552660,"name":"Veasna Duong","orcid":"0000-0003-0353-1678","position":4,"is_corresponding":false},{"id":475226,"name":"Philippe Dussart","orcid":"0000-0002-1931-3037","position":5,"is_corresponding":false},{"id":552656,"name":"Sophana Chea","orcid":"0000-0003-3187-3691","position":6,"is_corresponding":false},{"id":552655,"name":"Sreyngim Lay","orcid":"0000-0002-2388-8511","position":7,"is_corresponding":false},{"id":808211,"name":"Somnang Man","orcid":"0000-0002-2145-0954","position":8,"is_corresponding":false},{"id":1066971,"name":"Souv Kimsan","orcid":"0000-0001-8488-6221","position":9,"is_corresponding":false},{"id":808212,"name":"Chea Huch","orcid":"0000-0003-4791-9412","position":10,"is_corresponding":false},{"id":510618,"name":"Rithea Leang","orcid":"0000-0003-2645-7618","position":11,"is_corresponding":false},{"id":236329,"name":"Rekol Huy","orcid":"0000-0001-8552-3369","position":12,"is_corresponding":false},{"id":246069,"name":"Cara E. Brook","orcid":"0000-0003-4276-073X","position":13,"is_corresponding":false},{"id":344856,"name":"Jessica E. Manning","orcid":"0000-0003-0232-2196","position":14,"is_corresponding":false},{"id":517426,"name":"Christina Yek","orcid":"0000-0001-8293-3901","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-19T01:19:01.355412Z","pmid":"37333247","pmcid":"PMC10274987","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}