{"doi":"10.1101/2023.04.11.23288417","title":"Two artificial tears outbreak-associated cases of XDR <i>Pseudomonas aeruginosa</i> detected through whole genome sequencing-based surveillance","abstract":"ABSTRACT We describe two cases of XDR Pseudomonas aeruginosa infection caused by a strain of public health concern recently associated with a nationwide outbreak of contaminated artificial tears. Both cases were detected through database review of genomes in the Enhanced Detection System for Hospital-Associated Transmission (EDS-HAT), a routine genome sequencing-based surveillance program. We generated a high-quality reference genome for the outbreak strain from one of the case isolates from our center and examined the mobile elements encoding bla VIM-80 and bla GES-9 carbapenemases. We then used publicly available P. aeruginosa genomes to explore the genetic relatedness and antimicrobial resistance genes of the outbreak strain.","journal":"medRxiv","year":2023,"id":393171,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.929,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":356085,"name":"Vatsala Rangachar Srinivasa","orcid":"0000-0001-7376-8764","position":1,"is_corresponding":false},{"id":859596,"name":"Emma G. Mills","orcid":null,"position":2,"is_corresponding":false},{"id":356082,"name":"M. Patrick Griffith","orcid":"0000-0003-1012-881X","position":3,"is_corresponding":false},{"id":356084,"name":"Kady Waggle","orcid":"0009-0001-9237-9964","position":4,"is_corresponding":false},{"id":356087,"name":"Ashley Ayres","orcid":"0000-0001-8476-9770","position":5,"is_corresponding":false},{"id":1046650,"name":"Lora Pless","orcid":"0000-0003-0163-3689","position":6,"is_corresponding":false},{"id":334728,"name":"Graham M. Snyder","orcid":"0000-0001-5562-8880","position":7,"is_corresponding":false},{"id":281657,"name":"Lee H. Harrison","orcid":"0000-0002-3787-2705","position":8,"is_corresponding":false},{"id":302051,"name":"Daria Van Tyne","orcid":"0000-0001-7284-0103","position":9,"is_corresponding":false},{"id":334726,"name":"Alexander Sundermann","orcid":"0000-0002-2439-6287","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-19T01:19:01.355412Z","pmid":"37131775","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}