{"doi":"10.1101/2023.04.08.536123","title":"Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking","abstract":"SARS-CoV-2 continues to evolve and evade most existing neutralizing antibodies, including all clinically authorized antibodies. We have isolated and characterized two human monoclonal antibodies, 12-16 and 12-19, which exhibited neutralizing activities against all SARS-CoV-2 variants tested, including BQ.1.1 and XBB.1.5. They also blocked infection in hamsters challenged with Omicron BA.1 intranasally. Structural analyses revealed both antibodies targeted a conserved quaternary epitope located at the interface between the N-terminal domain and subdomain 1, revealing a previously unrecognized site of vulnerability on SARS-CoV-2 spike. These antibodies prevent viral receptor engagement by locking the receptor-binding domain of spike in the down conformation, revealing a novel mechanism of virus neutralization for non-RBD antibodies. Deep mutational scanning showed that SARS-CoV-2 could mutate to escape 12-19, but the responsible mutations are rarely found in circulating viruses. Antibodies 12-16 and 12-19 hold promise as prophylactic agents for immunocompromised persons who do not respond robustly to COVID-19 vaccines.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":390240,"datarank":0.692608853983258,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.30786645036402743,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.30786645036402743,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":12,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9519,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":615367,"name":"Ryan G. Casner","orcid":"0000-0002-2910-0908","position":1,"is_corresponding":false},{"id":482831,"name":"Yicheng Guo","orcid":"0000-0001-5357-660X","position":2,"is_corresponding":false},{"id":105623,"name":"Qian Wang","orcid":"0000-0001-9549-3140","position":3,"is_corresponding":false},{"id":350800,"name":"Sho Iketani","orcid":"0000-0002-3733-9556","position":4,"is_corresponding":false},{"id":78590,"name":"Jasper Fuk‐Woo Chan","orcid":"0000-0001-6336-6657","position":5,"is_corresponding":false},{"id":105621,"name":"Jian Yu","orcid":"0000-0001-8604-4538","position":6,"is_corresponding":false},{"id":839941,"name":"Bernadeta Dadonaite","orcid":"0000-0003-0908-6982","position":7,"is_corresponding":false},{"id":105620,"name":"Manoj S. Nair","orcid":"0000-0002-5994-3957","position":8,"is_corresponding":false},{"id":629820,"name":"Hiroshi Mohri","orcid":"0000-0003-3101-7625","position":9,"is_corresponding":false},{"id":527381,"name":"Eswar R. Reddem","orcid":"0000-0003-3054-5506","position":10,"is_corresponding":false},{"id":78571,"name":"Shuofeng Yuan","orcid":"0000-0001-7996-1119","position":11,"is_corresponding":false},{"id":78596,"name":"Vincent Kwok‐Man Poon","orcid":"0000-0002-7737-8912","position":12,"is_corresponding":false},{"id":623067,"name":"Chris Chung‐Sing Chan","orcid":"0000-0001-7089-4829","position":13,"is_corresponding":false},{"id":72027,"name":"Kwok‐Yung Yuen","orcid":"0000-0002-2083-1552","position":14,"is_corresponding":false},{"id":105636,"name":"Zizhang Sheng","orcid":"0000-0002-3253-3309","position":15,"is_corresponding":false},{"id":105637,"name":"Yaoxing Huang","orcid":"0000-0001-6270-1644","position":16,"is_corresponding":false},{"id":106715,"name":"Jesse D. Bloom","orcid":"0000-0003-1267-3408","position":17,"is_corresponding":false},{"id":105638,"name":"Lawrence Shapiro","orcid":"0000-0001-9943-8819","position":18,"is_corresponding":false},{"id":104013,"name":"David D. Ho","orcid":"0000-0003-1627-149X","position":19,"is_corresponding":false},{"id":105618,"name":"Lihong Liu","orcid":"0000-0003-3128-8513","position":0,"is_corresponding":true}],"reference_count":90,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:18:32.854511Z","pmid":"37090592","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}