{"doi":"10.1101/2023.04.05.535697","title":"TREM2 mediates MHCII-associated CD4 <sup>+</sup> T cell response against gliomas","abstract":"ABSTRACT Triggering receptor expressed on myeloid cells 2 (TREM2) was recently highlighted as a novel immune suppressive marker in peripheral tumors. The aim of this study was to characterize TREM2 expression in gliomas and investigate its contribution in glioma progression by using Trem2 -/- mouse line. Our results showed that higher TREM2 expression was correlated with poor prognosis in glioma patients. Unexpectedly, TREM2 deficiency did not have a beneficial effect in a pre-clinical model of glioma. The increased TREM2 expression in glioma was likely due to increased myeloid cell infiltration, as evidenced by our single-cell analysis showing that almost all microglia and macrophages in gliomas were TREM2 + . Furthermore, we found that deficiency of TREM2 impaired tumor-myeloid phagocytosis and MHCII presentation, and significantly reduced CD4 + T cells in tumor hemispheres. Our results revealed a previously unrecognized protective role of tumor-myeloid TREM2 in promoting MHCII-associated CD4 + T cell response against gliomas. SUMMARY Authors found that although higher TREM2 expression is correlated with poor prognosis in glioma patients, its absence has no beneficial effect in a pre-clinical model of glioma. Deficiency of TREM2 impairs myeloid cell phagocytosis of tumor debris, leading to a reduction in MHCII-dependent CD4 + anti-glioma immunity.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":394414,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":660361,"name":"Lingxiao Wang","orcid":"0000-0001-5819-4563","position":1,"is_corresponding":false},{"id":689266,"name":"Shunyi Zhao","orcid":"0000-0001-7265-0801","position":2,"is_corresponding":false},{"id":548594,"name":"Wenjing Zhang","orcid":"0000-0001-6931-900X","position":3,"is_corresponding":false},{"id":95209,"name":"Yuzhou Chang","orcid":"0000-0003-4893-1886","position":4,"is_corresponding":false},{"id":559379,"name":"Aastha Dheer","orcid":"0000-0003-3289-1402","position":5,"is_corresponding":false},{"id":1049905,"name":"Shan Gao","orcid":"0000-0001-5010-8376","position":6,"is_corresponding":false},{"id":1049906,"name":"Shengze Xu","orcid":"0009-0005-7581-8012","position":7,"is_corresponding":false},{"id":256583,"name":"Katayoun Ayasoufi","orcid":"0000-0002-3797-0823","position":8,"is_corresponding":false},{"id":296992,"name":"Rawan Al‐kharboosh","orcid":null,"position":9,"is_corresponding":false},{"id":556049,"name":"Manling Xie","orcid":"0000-0002-1747-1699","position":10,"is_corresponding":false},{"id":256585,"name":"Aaron J. Johnson","orcid":"0000-0002-7921-484X","position":11,"is_corresponding":false},{"id":230198,"name":"Haidong Dong","orcid":"0000-0002-5782-2983","position":12,"is_corresponding":false},{"id":278684,"name":"Alfredo Quiñones‐Hinojosa","orcid":"0000-0003-4262-5968","position":13,"is_corresponding":false},{"id":258025,"name":"Long‐Jun Wu","orcid":"0000-0001-8019-3380","position":14,"is_corresponding":false},{"id":255100,"name":"Jiaying Zheng","orcid":"0000-0002-7457-6198","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T01:19:14.590635Z","pmid":"37066234","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}