{"doi":"10.1101/2023.03.31.535073","title":"Induced neural phase precession through exogeneous electric fields","abstract":"The gradual shifting of preferred neural spiking relative to local field potentials (LFPs), known as phase precession, plays a prominent role in neural coding. Correlations between the phase precession and behavior have been observed throughout various brain regions. As such, phase precession is suggested to be a global neural mechanism that promotes local neuroplasticity. However, causal evidence and neuroplastic mechanisms of phase precession are lacking so far. Here we show a causal link between LFP dynamics and phase precession. In three experiments, we modulated LFPs in humans, a non-human primate, and computational models using alternating current stimulation. We show that continuous stimulation of motor cortex oscillations in humans lead to a gradual phase shift of maximal corticospinal excitability by ~90°. Further, exogenous alternating current stimulation induced phase precession in a subset of entrained neurons (~30%) in the non-human primate. Multiscale modeling of realistic neural circuits suggests that alternating current stimulation-induced phase precession is driven by NMDA-mediated synaptic plasticity. Altogether, the three experiments provide mechanistic and causal evidence for phase precession as a global neocortical process. Alternating current-induced phase precession and consequently synaptic plasticity is crucial for the development of novel therapeutic neuromodulation methods.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":393097,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9569,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":663723,"name":"Harry Tran","orcid":"0000-0003-2847-151X","position":1,"is_corresponding":false},{"id":1165926,"name":"Zhihe Zhao","orcid":"0009-0009-6866-8027","position":2,"is_corresponding":false},{"id":314174,"name":"Sina Shirinpour","orcid":"0000-0002-8267-6527","position":3,"is_corresponding":false},{"id":1167283,"name":"Zachary Haigh","orcid":null,"position":4,"is_corresponding":false},{"id":1167284,"name":"Jan J. Rotteveel","orcid":null,"position":5,"is_corresponding":false},{"id":998642,"name":"Nipun D. Perera","orcid":"0000-0002-8173-4529","position":6,"is_corresponding":false},{"id":240697,"name":"Ivan Alekseichuk","orcid":"0000-0002-2205-4910","position":7,"is_corresponding":false},{"id":320272,"name":"Jan Zimmermann","orcid":"0000-0003-3345-6074","position":8,"is_corresponding":false},{"id":240702,"name":"Alexander Opitz","orcid":"0000-0002-4851-1243","position":9,"is_corresponding":false},{"id":642995,"name":"Miles Wischnewski","orcid":"0000-0002-0056-6464","position":0,"is_corresponding":true}],"reference_count":121,"raw_metadata":null,"created_at":"2026-07-19T01:19:01.355412Z","pmid":"37034780","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}