{"doi":"10.1101/2023.03.29.534846","title":"Novel non hot spot modification in Fks1 of <i>Candida auris</i> confers echinocandin resistance","abstract":"ABSTRACT We determined echinocandin susceptibility and FKS1 genotypes of thirteen clinical isolates of Candida auris recovered from four patients at a tertiary care center in Salvador, Brazil. Three isolates were categorized as echinocandin-resistant and harbored a novel FKS1 mutation leading to an amino acid change W691L located downstream from hot-spot 1. When introduced to echinocandin-susceptible C. auris strains by CRISPR/Cas9, Fks1 W691L induced elevated MIC values to all echinocandins (ANF 16-32x; CAS &gt;64x; MCF &gt;64x).","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":406104,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1046022,"name":"Geselle Cancino-Prado","orcid":null,"position":1,"is_corresponding":false},{"id":1014882,"name":"João Nóbrega de Almeida","orcid":"0000-0002-3766-026X","position":2,"is_corresponding":false},{"id":1046023,"name":"Igor Brasil Brandão","orcid":null,"position":3,"is_corresponding":false},{"id":1046024,"name":"Renata Tigulini de Souza Peral","orcid":null,"position":4,"is_corresponding":false},{"id":1014883,"name":"Arnaldo Lopes Colombo","orcid":"0000-0003-0793-8491","position":5,"is_corresponding":false},{"id":336885,"name":"David S. Perlin","orcid":"0000-0002-1268-5524","position":6,"is_corresponding":false},{"id":808269,"name":"Milena Kordalewska","orcid":"0000-0001-8479-0721","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-19T01:20:59.152593Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}