{"doi":"10.1101/2023.03.07.531585","title":"Along-Tract Statistical Mapping of Microstructural Abnormalities in Bipolar Disorder: A Pilot Study","abstract":"Investigating brain circuitry involved in bipolar disorder (BD) is key to discovering brain biomarkers for genetic and interventional studies of the disorder. Even so, prior research has not provided a fine-scale spatial mapping of brain microstructural differences in BD. In this pilot diffusion MRI dataset, we used BUndle ANalytics (BUAN), a recently developed analytic approach for tractography, to extract, map, and visualize the profile of microstructural abnormalities on a 3D model of fiber tracts in people with BD (N=38) and healthy controls (N=49), and investigate along-tract white matter (WM) microstructural differences between these groups. Using the BUAN pipeline, BD was associated with lower mean Fractional Anisotropy (FA) in fronto-limbic and interhemispheric pathways and higher mean FA in posterior bundles relative to controls. BUAN combines tractography and anatomical information to capture distinct along-tract effects on WM microstructure that may aid in classifying diseases based on anatomical differences.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":395971,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":29.844511487584125,"corpus_rank":8690,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.734,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":262623,"name":"Bramsh Q. Chandio","orcid":"0000-0002-8949-4937","position":1,"is_corresponding":false},{"id":517575,"name":"Nikhil J. Dhinagar","orcid":"0000-0003-2424-4854","position":2,"is_corresponding":false},{"id":1160601,"name":"Emily Laltoo","orcid":null,"position":3,"is_corresponding":false},{"id":260694,"name":"Genevieve McPhilemy","orcid":"0000-0002-9218-119X","position":4,"is_corresponding":false},{"id":661398,"name":"Fiona M. Martyn","orcid":"0000-0002-0281-0985","position":5,"is_corresponding":false},{"id":297639,"name":"Brian Hallahan","orcid":"0000-0003-0518-9757","position":6,"is_corresponding":false},{"id":62400,"name":"Colm McDonald","orcid":"0000-0003-1661-5192","position":7,"is_corresponding":false},{"id":51712,"name":"Paul M. Thompson","orcid":"0000-0002-4720-8867","position":8,"is_corresponding":false},{"id":107784,"name":"Dara M. Cannon","orcid":"0000-0001-7378-3411","position":9,"is_corresponding":false},{"id":259216,"name":"Leila Nabulsi","orcid":"0000-0001-9448-7769","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T01:19:27.044553Z","pmid":"36945403","pmcid":"PMC10028925","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}