{"doi":"10.1101/2023.03.02.530850","title":"Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection","abstract":"SUMMARY Memory B cells are key providers of long-lived immunity against infectious disease, yet in chronic viral infection they do not produce effective protection. How chronic viral infection disrupts memory B cell development, and whether such changes are reversible, remains unknown. Here, we uncover type-I interferon (IFN-I) dynamics as a key determinant in shaping chronic memory B cell development. Through single-cell (sc)ATAC-sequencing and scRNA-sequencing, we identified a unique memory subset enriched for IFN-stimulated genes (ISGs) during chronic lymphocytic choriomeningitis virus infection. Blockade of IFNAR-1 early in infection transformed the chromatin landscape of chronic memory B cells, decreasing accessibility at ISG-inducing transcription factor binding motifs and inducing a phenotypic change in the dominating memory B cell subset. However, timing was critical, with memory B cells resistant to intervention after 4 weeks post-infection. Together, our research identifies a key mechanism to instruct memory B cell identity during viral infection. One Sentence Summary: IFN dynamics in chronic versus acute viral infection determines memory B cell development.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":398654,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1174734,"name":"Hui Xu","orcid":"0000-0002-0932-5026","position":1,"is_corresponding":false},{"id":683185,"name":"Jack Polmear","orcid":"0000-0003-3449-4128","position":2,"is_corresponding":false},{"id":1913,"name":"Christopher Szeto","orcid":"0000-0003-3784-5210","position":3,"is_corresponding":false},{"id":1174735,"name":"Ee Shan Pang","orcid":"0000-0003-4325-6260","position":4,"is_corresponding":false},{"id":1121561,"name":"Mansi Gupta","orcid":"0000-0001-9506-1911","position":5,"is_corresponding":false},{"id":414019,"name":"Justin J. Taylor","orcid":"0000-0001-9718-2901","position":6,"is_corresponding":false},{"id":237492,"name":"Katherine Jackson","orcid":"0000-0002-9952-7069","position":7,"is_corresponding":false},{"id":447938,"name":"Angela Nguyen","orcid":"0000-0003-1610-515X","position":8,"is_corresponding":false},{"id":447942,"name":"Nicole L. La Gruta","orcid":"0000-0001-5358-9363","position":9,"is_corresponding":false},{"id":86811,"name":"Luciano G. Martelotto","orcid":"0000-0002-9625-1183","position":10,"is_corresponding":false},{"id":656808,"name":"Ian A. Parish","orcid":"0000-0003-3528-478X","position":11,"is_corresponding":false},{"id":1174736,"name":"Meredith O’Keeffe","orcid":"0000-0002-0779-4654","position":12,"is_corresponding":false},{"id":270265,"name":"Christopher D. Scharer","orcid":"0000-0001-7716-8504","position":13,"is_corresponding":false},{"id":447940,"name":"Stéphanie Gras","orcid":"0000-0001-7416-038X","position":14,"is_corresponding":false},{"id":683190,"name":"Kim L. Good‐Jacobson","orcid":"0000-0003-1891-7274","position":15,"is_corresponding":false},{"id":683186,"name":"Lucy Cooper","orcid":"0000-0002-7153-5358","position":0,"is_corresponding":true}],"reference_count":108,"raw_metadata":null,"created_at":"2026-07-19T01:19:47.744358Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}