{"doi":"10.1101/2023.03.01.530655","title":"CD8+ cells and small viral reservoirs facilitate post-ART control of SIV in Mauritian cynomolgus macaques","abstract":"Sustainable HIV remission after antiretroviral therapy (ART) withdrawal, or post-treatment control (PTC), remains a top priority for HIV treatment. We observed surprising PTC in an MHC-haplomatched cohort of MHC-M3+ SIVmac239+ Mauritian cynomolgus macaques (MCMs) initiated on ART at two weeks post-infection (wpi). For six months after ART withdrawal, we observed undetectable or transient viremia in seven of eight MCMs. In vivo depletion of CD8α+ cells induced rebound in all animals, indicating the PTC was mediated, at least in part, by CD8α+ cells. We found that MCMs had smaller acute viral reservoirs than a cohort of identically infected rhesus macaques, a population that rarely develops PTC. The mechanisms by which unusually small viral reservoirs and CD8α+ cell-mediated virus suppression enable PTC can be investigated using this MHC-haplomatched MCM model. Further, defining the immunologic mechanisms that engender PTC in this model may identify therapeutic targets for inducing durable HIV remission in humans.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":403475,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":540697,"name":"Lea M. Matschke","orcid":"0000-0003-4243-9292","position":1,"is_corresponding":false},{"id":372354,"name":"Ryan V. Moriarty","orcid":"0000-0001-7100-1906","position":2,"is_corresponding":false},{"id":473624,"name":"Alexis J. Balgeman","orcid":"0000-0003-2627-7975","position":3,"is_corresponding":false},{"id":967050,"name":"Abigail J. Weaver","orcid":null,"position":4,"is_corresponding":false},{"id":473623,"name":"Amy Ellis","orcid":"0000-0002-6503-1399","position":5,"is_corresponding":false},{"id":332158,"name":"Andrea M. Weiler","orcid":"0000-0002-7130-8235","position":6,"is_corresponding":false},{"id":612662,"name":"Lee C. Winchester","orcid":"0000-0002-6118-024X","position":7,"is_corresponding":false},{"id":259563,"name":"Courtney V. Fletcher","orcid":"0000-0002-3703-7849","position":8,"is_corresponding":false},{"id":332162,"name":"Thomas C. Friedrich","orcid":"0000-0001-9831-6895","position":9,"is_corresponding":false},{"id":233486,"name":"Brandon F. Keele","orcid":"0000-0002-2381-1151","position":10,"is_corresponding":false},{"id":246460,"name":"David H. O’Connor","orcid":"0000-0003-2139-470X","position":11,"is_corresponding":false},{"id":353515,"name":"Jessica D. Lang","orcid":"0000-0001-9700-4785","position":12,"is_corresponding":false},{"id":532233,"name":"Matthew R. Reynolds","orcid":"0000-0002-1484-6408","position":13,"is_corresponding":false},{"id":333888,"name":"Shelby L. O’Connor","orcid":"0000-0003-0183-5010","position":14,"is_corresponding":false},{"id":560501,"name":"Olivia E. Harwood","orcid":"0000-0002-0315-9645","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:20:36.280647Z","pmid":"36909458","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}