{"doi":"10.1101/2023.03.01.530323","title":"Subset-specific and temporal control of effector and memory CD4+ T cell survival","abstract":"Following their proliferative expansion and differentiation into effector cells like Th1, Tfh, and T central memory precursors (Tcmp), most effector CD4+ T cells die, while some survive and become memory cells. Here, we explored how Bcl-2 family members controlled the survival of CD4+ T cells during distinct phases of mouse acute LCMV infection. During expansion, we found that Th1 cells dominated the response, downregulated expression of Bcl-2, and did not require Bcl-2 for survival. Instead, they relied on the anti-apoptotic protein, A1 for survival. Similarly, Th17 cells in an EAE model also depended on A1 for survival. However, after the peak of the response, CD4+ effector T cells required Bcl-2 to counteract Bim to aid their transition into memory. This Bcl-2 dependence persisted in established memory CD4+ T cells. Combined, these data show a temporal switch in Bcl-2 family-mediated survival of CD4+ T cells over the course of an immune response. This knowledge can help improve T cell survival to boost immunity and conversely, target pathogenic T cells.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":394242,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":231619,"name":"Autumn Ferguson","orcid":"0009-0006-7073-8029","position":1,"is_corresponding":false},{"id":879496,"name":"Aditi Paranjpe","orcid":"0000-0002-3566-3993","position":2,"is_corresponding":false},{"id":1120510,"name":"Eileen E. Cianciolo","orcid":null,"position":3,"is_corresponding":false},{"id":909157,"name":"Jonathan D. Katz","orcid":"0000-0002-9864-2268","position":4,"is_corresponding":false},{"id":242738,"name":"Marco J. Herold","orcid":"0000-0001-7539-7581","position":5,"is_corresponding":false},{"id":270445,"name":"David A. Hildeman","orcid":"0000-0002-0421-8483","position":6,"is_corresponding":false},{"id":1168595,"name":"Sharmila Shanmuganad","orcid":"0000-0002-0487-0527","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T01:19:10.334330Z","pmid":"36909576","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}