{"doi":"10.1101/2023.02.28.530490","title":"Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies","abstract":"Organism aging occurs at the multicellular level; however, how pro-longevity mechanisms slow down aging in different cell types remains unclear. We generated single-cell transcriptomic atlases across the lifespan of Caenorhabditis elegans under different pro-longevity conditions (http://mengwanglab.org/atlas). We found cell-specific, age-related changes across somatic and germ cell types and developed transcriptomic aging clocks for different tissues. These clocks enabled us to determine tissue-specific aging-slowing effects of different pro-longevity mechanisms, and identify major cell types sensitive to these regulations. Additionally, we provided a systemic view of alternative polyadenylation events in different cell types, as well as their cell-type-specific changes during aging and under different pro-longevity conditions. Together, this study provides molecular insights into how aging occurs in different cell types and how they respond to pro-longevity strategies.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":389972,"datarank":0.6297001966218365,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.21381188828586925,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.21381188828586925,"corpus_percentile":68.57739614759805,"corpus_rank":4063,"citation_count":15,"citer_count":13,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6402,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":551915,"name":"Yanyan Qi","orcid":"0000-0003-0537-1540","position":1,"is_corresponding":false},{"id":827265,"name":"Qinghao Zhang","orcid":"0000-0002-5744-9859","position":2,"is_corresponding":false},{"id":1161196,"name":"Aaron Mohammed","orcid":"0000-0001-7673-3399","position":3,"is_corresponding":false},{"id":827262,"name":"Yi-Tang Lee","orcid":"0000-0002-0413-4706","position":4,"is_corresponding":false},{"id":395772,"name":"Youchen Guan","orcid":"0000-0002-6570-5293","position":5,"is_corresponding":false},{"id":242235,"name":"Hongjie Li","orcid":"0000-0002-7332-7122","position":6,"is_corresponding":false},{"id":1161197,"name":"Yusi Fu","orcid":"0000-0002-7970-5702","position":7,"is_corresponding":false},{"id":245729,"name":"Meng C. Wang","orcid":"0000-0002-5898-6007","position":8,"is_corresponding":false},{"id":288971,"name":"Shihong Max Gao","orcid":"0000-0003-3238-8348","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T01:18:32.854511Z","pmid":"36909655","pmcid":"PMC10002668","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}