{"doi":"10.1101/2023.02.20.529261","title":"Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity","abstract":"Abstract Regulatory T (Treg) cells are instrumental in establishing immunological tolerance. However, the precise effector mechanisms by which Treg cells control a specific type of immune response in a given tissue remains unresolved. By simultaneously studying Treg cells from different tissue origins under systemic autoimmunity, here we show that IL-27 is specifically produced by intestinal Treg cells to regulate Th17 immunity. Selectively increased intestinal Th17 responses in mice with Treg cell-specific IL-27 ablation led to exacerbated intestinal inflammation and colitis-associated cancer, but also helped protect against enteric bacterial infection. Furthermore, single-cell transcriptomic analysis has identified a CD83 + TCF1 + Treg cell subset that is distinct from previously characterized intestinal Treg cell populations as the main IL-27 producers. Collectively, our study uncovers a novel Treg cell suppression mechanism crucial for controlling a specific type of immune response in a particular tissue, and provides further mechanistic insights into tissue-specific Treg cell-mediated immune regulation.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":394184,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1030870,"name":"Cheng-Jang Wu","orcid":"0000-0002-7640-5915","position":1,"is_corresponding":false},{"id":420435,"name":"Sunglim Cho","orcid":"0000-0003-3109-0216","position":2,"is_corresponding":false},{"id":845569,"name":"Rasika Patkar","orcid":"0000-0002-6664-5659","position":3,"is_corresponding":false},{"id":414229,"name":"Ling-Li Lin","orcid":"0000-0002-6547-4739","position":4,"is_corresponding":false},{"id":414230,"name":"Mei‐Chi Chen","orcid":"0000-0002-9984-3459","position":5,"is_corresponding":false},{"id":531091,"name":"Elisabeth Israelsson","orcid":null,"position":6,"is_corresponding":false},{"id":1031492,"name":"Joanne Betts","orcid":null,"position":7,"is_corresponding":false},{"id":1030872,"name":"Magdalena Niedzielska","orcid":"0000-0001-9618-7970","position":8,"is_corresponding":false},{"id":238813,"name":"Shefali A. Patel","orcid":null,"position":9,"is_corresponding":false},{"id":238812,"name":"Han G. Duong","orcid":null,"position":10,"is_corresponding":false},{"id":458486,"name":"Romana R. Gerner","orcid":"0000-0003-2377-6509","position":11,"is_corresponding":false},{"id":1168869,"name":"Chia‐Yun Hsu","orcid":null,"position":12,"is_corresponding":false},{"id":1031493,"name":"Matthew C. Catley","orcid":null,"position":13,"is_corresponding":false},{"id":31595,"name":"Rose A. Maciewicz","orcid":"0000-0002-5371-7828","position":14,"is_corresponding":false},{"id":280720,"name":"Hiutung Chu","orcid":"0000-0001-7489-0446","position":15,"is_corresponding":false},{"id":225259,"name":"Manuela Raffatellu","orcid":"0000-0001-6487-4215","position":16,"is_corresponding":false},{"id":225253,"name":"John T. Chang","orcid":"0000-0003-0873-6218","position":17,"is_corresponding":false},{"id":236080,"name":"Li‐Fan Lu","orcid":"0000-0002-9727-0036","position":18,"is_corresponding":false},{"id":696723,"name":"Chia‐Hao Lin","orcid":"0000-0001-6510-8483","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:19:10.334330Z","pmid":"36865314","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}