{"doi":"10.1101/2023.02.14.528512","title":"A hyper-quiescent chromatin state formed during aging is reversed by regeneration","abstract":"Epigenetic alterations are a key hallmark of aging but have been limitedly explored in tissues. Here, using naturally aged murine liver as a model and extending to other quiescent tissues, we find that aging is driven by temporal chromatin alterations that promote a refractory cellular state and compromise cellular identity. Using an integrated multi-omics approach, and the first direct visualization of aged chromatin we find that globally, old cells show H3K27me3-driven broad heterochromatinization and transcription suppression. At the local level, site-specific loss of H3K27me3 over promoters of genes encoding developmental transcription factors leads to expression of otherwise non-hepatocyte markers. Interestingly, liver regeneration reverses H3K27me3 patterns and rejuvenates multiple molecular and physiological aspects of the aged liver.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":392972,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":685306,"name":"James R. Occean","orcid":"0000-0002-6823-6381","position":1,"is_corresponding":false},{"id":411119,"name":"Daniël P. Melters","orcid":"0000-0003-4809-0562","position":2,"is_corresponding":false},{"id":425306,"name":"Changyou Shi","orcid":null,"position":3,"is_corresponding":false},{"id":424212,"name":"Lin Wang","orcid":"0000-0002-2148-1929","position":4,"is_corresponding":false},{"id":563067,"name":"Stephanie Stransky","orcid":"0000-0003-0844-2754","position":5,"is_corresponding":false},{"id":640361,"name":"Maı̀re E. Doyle","orcid":"0000-0002-0478-4979","position":6,"is_corresponding":false},{"id":467285,"name":"Chang‐Yi Cui","orcid":"0000-0002-9856-9427","position":7,"is_corresponding":false},{"id":304886,"name":"Michael Delannoy","orcid":"0009-0005-5536-448X","position":8,"is_corresponding":false},{"id":210682,"name":"JINSHUI FAN","orcid":null,"position":9,"is_corresponding":false},{"id":1027711,"name":"Eliza Slama","orcid":"0000-0002-7997-8831","position":10,"is_corresponding":false},{"id":264195,"name":"Josephine M. Egan","orcid":"0000-0002-8945-0053","position":11,"is_corresponding":false},{"id":275722,"name":"Supriyo De","orcid":"0000-0002-2075-7655","position":12,"is_corresponding":false},{"id":1027712,"name":"Steven C. Cunningham","orcid":"0000-0001-7758-7717","position":13,"is_corresponding":false},{"id":258549,"name":"Rafael de Cabo","orcid":"0000-0003-2830-5693","position":14,"is_corresponding":false},{"id":247704,"name":"Simone Sidoli","orcid":"0000-0001-9073-6641","position":15,"is_corresponding":false},{"id":411120,"name":"Yamini Dalal","orcid":"0000-0002-7655-6182","position":16,"is_corresponding":false},{"id":275721,"name":"Payel Sen","orcid":"0000-0003-2809-0901","position":17,"is_corresponding":false},{"id":1027710,"name":"Na Yang","orcid":"0000-0002-6956-6630","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T01:19:01.355412Z","pmid":"36824822","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}