{"doi":"10.1101/2023.02.09.527908","title":"Cell state transition analysis identifies interventions that improve control of <i>M. tuberculosis</i> infection by susceptible macrophages","abstract":"Abstract Understanding cell state transitions and purposefully controlling them to improve therapies is a longstanding challenge in biological research and medicine. Here, we identify a transcriptional signature that distinguishes activated macrophages from TB-susceptible and TB-resistant mice. We then apply the cSTAR (cell State Transition Assessment and Regulation) approach to data from screening-by-RNA sequencing to identify chemical perturbations that shift the. transcriptional state of the TB-susceptible macrophages towards that of TB-resistant cells. Finally, we demonstrate that the compounds identified with this approach enhance resistance of the TB-susceptible mouse macrophages to virulent M. tuberculosis .","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":403007,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9608,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":320172,"name":"Oleksii S. Rukhlenko","orcid":"0000-0003-1863-4987","position":1,"is_corresponding":false},{"id":351318,"name":"Sujoy Chatterjee","orcid":"0000-0001-9001-5780","position":2,"is_corresponding":false},{"id":351316,"name":"Bidisha Bhattacharya","orcid":"0009-0001-1294-1516","position":3,"is_corresponding":false},{"id":1063980,"name":"Emily Wood","orcid":"0000-0002-1466-5615","position":4,"is_corresponding":false},{"id":1088161,"name":"Marina V. Kasaikina","orcid":null,"position":5,"is_corresponding":false},{"id":320176,"name":"Boris Ν. Kholodenko","orcid":"0000-0002-9483-4975","position":6,"is_corresponding":false},{"id":558517,"name":"Alexander A. Gimelbrant","orcid":"0000-0001-6986-0285","position":7,"is_corresponding":false},{"id":351323,"name":"Igor Kramnik","orcid":"0000-0001-6511-9246","position":8,"is_corresponding":false},{"id":559044,"name":"Shivraj M. Yabaji","orcid":"0000-0002-5793-1661","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T01:20:32.588152Z","pmid":"36798271","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}