{"doi":"10.1101/2023.02.09.23285714","title":"Association of Healthy Dietary Patterns and Cardiorespiratory Fitness in the Community","abstract":"Abstract Aims To evaluate the associations of dietary indices and quantitative CRF measures in a large, community-based sample harnessing metabolomic profiling to interrogate shared biology. Methods Framingham Heart Study (FHS) participants underwent maximum effort cardiopulmonary exercise tests for CRF quantification (via peak VO 2 ) and completed semi-quantitative FFQs. Dietary quality was assessed by the Alternative Healthy Eating Index (AHEI) and Mediterranean-style Diet Score (MDS), and fasting blood concentrations of 201 metabolites were quantified. Results In 2380 FHS participants (54±9 years, 54% female, BMI 28±5 kg/m 2 ), 1-SD higher AHEI and MDS were associated with 5.1% (1.2 ml/kg/min, p<0.0001) and 4.4% (1.0 ml/kg/min, p<0.0001) greater peak VO 2 in linear models adjusted for age, sex, total energy intake, cardiovascular risk factors, and physical activity. In participants with metabolite profiling (N=1154), 24 metabolites were concordantly associated with both dietary indices and peak VO 2 in multivariable-adjusted linear models (FDR<5%). These metabolites included C6 and C7 carnitines, C16:0 ceramide, and dimethylguanidino valeric acid, which were higher with lower CRF and poorer dietary quality and are known markers of insulin resistance and cardiovascular risk. Conversely, C38:7 phosphatidylcholine plasmalogen and C38:7 and C40:7 phosphatidylethanolamine plasmalogens were associated with higher CRF and favorable dietary quality and may link to lower cardiometabolic risk. Conclusion Higher diet quality is associated with greater CRF cross-sectionally in a middle-aged community-dwelling sample, and metabolites highlight potential shared favorable effects on health.","journal":"medRxiv","year":2023,"id":392178,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":705695,"name":"Priya Gajjar","orcid":null,"position":1,"is_corresponding":false},{"id":291150,"name":"Maura E. Walker","orcid":"0000-0001-9935-4113","position":2,"is_corresponding":false},{"id":751450,"name":"Patricia E. Miller","orcid":"0000-0002-0141-717X","position":3,"is_corresponding":false},{"id":337722,"name":"Vanessa Xanthakis","orcid":"0000-0002-7352-621X","position":4,"is_corresponding":false},{"id":326582,"name":"Venkatesh L. Murthy","orcid":"0000-0002-7901-1321","position":5,"is_corresponding":false},{"id":230820,"name":"Martin G. Larson","orcid":"0000-0002-9631-1254","position":6,"is_corresponding":false},{"id":24661,"name":"Ramachandran S. Vasan","orcid":"0000-0001-7357-5970","position":7,"is_corresponding":false},{"id":251876,"name":"Ravi V. Shah","orcid":"0000-0002-4471-7156","position":8,"is_corresponding":false},{"id":255092,"name":"Gregory D. Lewis","orcid":"0000-0001-8108-8240","position":9,"is_corresponding":false},{"id":255091,"name":"Matthew Nayor","orcid":"0000-0002-6993-9396","position":10,"is_corresponding":false},{"id":1042495,"name":"Michael Mi","orcid":null,"position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:18:52.232318Z","pmid":"36798343","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}