{"doi":"10.1101/2023.02.07.527500","title":"Subdural CMOS optical probe (SCOPe) for bidirectional neural interfacing","abstract":"Optical neurotechnologies use light to interface with neurons and can monitor and manipulate neural activity with high spatial-temporal precision over large cortical extents. While there has been significant progress in miniaturizing microscope for head-mounted configurations, these existing devices are still very bulky and could never be fully implanted. Any viable translation of these technologies to human use will require a much more noninvasive, fully implantable form factor. Here, we leverage advances in microelectronics and heterogeneous optoelectronic packaging to develop a transformative, ultrathin, miniaturized device for bidirectional optical stimulation and recording: the subdural CMOS Optical Probe (SCOPe). By being thin enough to lie entirely within the subdural space of the primate brain, SCOPe defines a path for the eventual human translation of a new generation of brain-machine interfaces based on light.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":390211,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9503,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":743035,"name":"Heyu Yin","orcid":"0000-0002-6336-7972","position":1,"is_corresponding":false},{"id":570115,"name":"Ilke Uguz","orcid":"0000-0001-8898-876X","position":2,"is_corresponding":false},{"id":661999,"name":"Agrita Dubey","orcid":"0000-0002-2239-9177","position":3,"is_corresponding":false},{"id":662000,"name":"Katie Wingel","orcid":"0000-0003-4006-2284","position":4,"is_corresponding":false},{"id":831449,"name":"John Choi","orcid":"0009-0007-4567-6409","position":5,"is_corresponding":false},{"id":510486,"name":"Sajjad Moazeni","orcid":"0000-0003-1819-0714","position":6,"is_corresponding":false},{"id":1161532,"name":"Yatin Gilhotra","orcid":"0000-0002-6364-3324","position":7,"is_corresponding":false},{"id":1027159,"name":"Victoria Andino-Pavlovsky","orcid":"0000-0003-2001-8059","position":8,"is_corresponding":false},{"id":1162009,"name":"Adam Banees","orcid":null,"position":9,"is_corresponding":false},{"id":254312,"name":"Vivek Boominathan","orcid":"0000-0003-4875-3135","position":10,"is_corresponding":false},{"id":34016,"name":"Jacob T. Robinson","orcid":"0000-0002-3509-3054","position":11,"is_corresponding":false},{"id":254314,"name":"Ashok Veeraraghavan","orcid":"0000-0001-5043-7460","position":12,"is_corresponding":false},{"id":567011,"name":"Vincent A. Pieribone","orcid":"0000-0002-5836-5454","position":13,"is_corresponding":false},{"id":253684,"name":"Bijan Pesaran","orcid":"0000-0003-4116-0038","position":14,"is_corresponding":false},{"id":55282,"name":"Kenneth L. Shepard","orcid":"0000-0003-0665-6775","position":15,"is_corresponding":false},{"id":510484,"name":"Eric H. Pollmann","orcid":"0000-0001-5118-5031","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-19T01:18:32.854511Z","pmid":"36798295","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}