{"doi":"10.1101/2023.02.07.527360","title":"Colocalization of Cancer Associated Biomarkers on Single Extracellular Vesicles for Early Cancer Detection","abstract":"Abstract Detection of cancer early, when it is most treatable, remains a significant challenge due to the lack of diagnostic methods sufficiently sensitive to detect nascent tumors. Early-stage tumors are small relative to their tissue of origin, heterogeneous, and infrequently manifest in clinical symptoms. Detection of their presence is made more difficult by a lack of abundant tumor-specific indicators (i.e., protein biomarkers, circulating tumor DNA, etc.) that would enable detection using a non-invasive diagnostic assay. In addition, many benign conditions manifest in a similar manner, thus discriminating an early-stage cancerous lesion from a benign tumor can present additional challenges and result in unnecessary medical procedures. To overcome these obstacles, we have developed a liquid biopsy assay that interrogates circulating extracellular vesicles (EVs) to detect tumor-specific biomarkers colocalized on the surface of individual EVs. Extracellular vesicles from all cell types, including early-stage tumors, are known to be abundant in blood, are remarkably stable, and serve as a biopsy of their cell of origin. The detection of a colocalized combination of cancer associated biomarkers that provide tumor specificity on the surface of extracellular vesicles enables the discrimination of early- and late-stage cancer from non-malignant conditions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":398427,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1174641,"name":"Laura T. Bortolin","orcid":"0000-0003-4444-6058","position":1,"is_corresponding":false},{"id":1174865,"name":"Dan Gusenleitner","orcid":null,"position":2,"is_corresponding":false},{"id":1174642,"name":"Jonian Grosha","orcid":"0000-0001-7713-0848","position":3,"is_corresponding":false},{"id":683759,"name":"Ibukunoluwapo O. Zabroski","orcid":"0000-0003-2444-635X","position":4,"is_corresponding":false},{"id":560550,"name":"Kelly M. Biette","orcid":"0000-0001-6920-0068","position":5,"is_corresponding":false},{"id":1174643,"name":"Sanchari Banerjee","orcid":"0000-0003-0433-2427","position":6,"is_corresponding":false},{"id":1174866,"name":"Christopher R. Sedlak","orcid":null,"position":7,"is_corresponding":false},{"id":886188,"name":"Delaney M. Byrne","orcid":"0000-0003-3752-9648","position":8,"is_corresponding":false},{"id":1174644,"name":"Bilal F. Hamzeh","orcid":"0000-0003-0615-2972","position":9,"is_corresponding":false},{"id":1174645,"name":"MacKenzie S. King","orcid":"0000-0001-7035-4742","position":10,"is_corresponding":false},{"id":1174646,"name":"Lauren T. Cuoco","orcid":"0000-0001-5640-7879","position":11,"is_corresponding":false},{"id":1174647,"name":"Timothy Santos-Heiman","orcid":"0009-0003-5059-4986","position":12,"is_corresponding":false},{"id":1174648,"name":"Peter A. Duff","orcid":"0009-0000-3289-7201","position":13,"is_corresponding":false},{"id":4357,"name":"Emily S. Winn-Deen","orcid":"0000-0003-4146-3274","position":14,"is_corresponding":false},{"id":636836,"name":"Toumy Guettouche","orcid":"0009-0005-7342-3279","position":15,"is_corresponding":false},{"id":563129,"name":"Dawn Mattoon","orcid":"0009-0001-4198-5614","position":16,"is_corresponding":false},{"id":1174649,"name":"Eric K. Huang","orcid":"0000-0003-1665-6605","position":17,"is_corresponding":false},{"id":71618,"name":"Randy Schekman","orcid":"0000-0001-8615-6409","position":18,"is_corresponding":false},{"id":1174650,"name":"Anthony D. 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