{"doi":"10.1101/2023.01.25.525506","title":"The memory of pathogenic IgE is contained within CD23 <sup>+</sup> IgG1 <sup>+</sup> memory B cells poised to switch to IgE in food allergy","abstract":"Abstract Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23 + IgG1 + memory B cells arising in type 2 responses that contain peanut specific clones and generate IgE cells on activation. These ‘type2-marked’ IgG1 + memory B cells differentially express IL-4/IL-13 regulated genes FCER2 / CD23, IL4R , and germline IGHE and carry highly mutated B cell receptors (BCRs). Further, high affinity memory B cells specific for the main peanut allergen Ara h 2 mapped to the population of ‘type2-marked’ IgG1 + memory B cells and included convergent BCRs across different individuals. Our findings indicate that CD23 + IgG1 + memory B cells transcribing germline IGHE are a unique memory population containing precursors of pathogenic IgE. One-Sentence Summary We describe a unique population of IgG + memory B cells poised to switch to IgE that contains high affinity allergen-specific clones in peanut allergy.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":390341,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9485,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":255166,"name":"Kenneth B. Hoehn","orcid":"0000-0003-0411-4307","position":1,"is_corresponding":false},{"id":1161686,"name":"Takayuki Ota","orcid":"0000-0001-6249-0664","position":2,"is_corresponding":false},{"id":853317,"name":"Carlos J. Aranda","orcid":"0000-0001-6224-9352","position":3,"is_corresponding":false},{"id":1161687,"name":"Sara L. Friedman","orcid":"0000-0001-9637-2543","position":4,"is_corresponding":false},{"id":853319,"name":"Weslley Fernandes‐Braga","orcid":"0000-0001-8349-7099","position":5,"is_corresponding":false},{"id":1161688,"name":"Alefiyah Malbari","orcid":"0000-0003-4354-0421","position":6,"is_corresponding":false},{"id":6493,"name":"Steven H. Kleinstein","orcid":"0000-0003-4957-1544","position":7,"is_corresponding":false},{"id":241620,"name":"Scott H. Sicherer","orcid":"0000-0003-0036-0439","position":8,"is_corresponding":false},{"id":105235,"name":"Maria A. Curotto de Lafaille","orcid":"0000-0002-3510-3777","position":9,"is_corresponding":false},{"id":105270,"name":"Miyo Ota","orcid":null,"position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T01:18:32.854511Z","pmid":"36747707","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}