{"doi":"10.1101/2023.01.25.23284971","title":"Vaccine-elicited B and T cell immunity to SARS-CoV-2 is impaired in chronic lung disease patients","abstract":"The protection afforded by vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to individuals with chronic lung disease is not well established. To understand how chronic lung disease impacts SARS-CoV-2 vaccine-elicited immunity we performed deep immunophenotyping of the humoral and cell mediated SARS-CoV-2 vaccine response in an investigative cohort of vaccinated patients with diverse pulmonary conditions including asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease (ILD). Compared to healthy controls, 48% of vaccinated patients with chronic lung diseases had reduced antibody titers to the SARS-CoV-2 vaccine antigen as early as 3-4 months after vaccination, correlating with decreased vaccine-specific memory B cells. Vaccine-specific CD4 and CD8 T cells were also significantly reduced in patients with asthma, COPD, and a subset of ILD patients compared to healthy controls. These findings reveal the complex nature of vaccine-elicited immunity in high-risk patients with chronic lung disease.","journal":"medRxiv","year":2023,"id":398311,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9603,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":626276,"name":"Katja Aviszus","orcid":"0000-0003-0036-8027","position":1,"is_corresponding":false},{"id":681606,"name":"Pearlanne Zelarney","orcid":"0000-0001-5713-9749","position":2,"is_corresponding":false},{"id":337409,"name":"Shu‐Yi Liao","orcid":"0000-0001-9477-3837","position":3,"is_corresponding":false},{"id":472939,"name":"Anthony N. Gerber","orcid":"0000-0002-5280-8218","position":4,"is_corresponding":false},{"id":24990,"name":"Barry J. Make","orcid":"0000-0003-4349-8745","position":5,"is_corresponding":false},{"id":247340,"name":"Michael E. Wechsler","orcid":"0000-0003-3505-2946","position":6,"is_corresponding":false},{"id":345661,"name":"Philippa Marrack","orcid":"0000-0003-1883-3687","position":7,"is_corresponding":false},{"id":297883,"name":"R. Lee Reinhardt","orcid":"0000-0001-7798-9732","position":8,"is_corresponding":false},{"id":487972,"name":"Haolin Liu","orcid":"0009-0002-5583-2974","position":0,"is_corresponding":true}],"reference_count":93,"raw_metadata":null,"created_at":"2026-07-19T01:19:43.776284Z","pmid":"36747750","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}