{"doi":"10.1101/2023.01.24.525387","title":"Cell Instance Segmentation Via Multi-Scale Non-Local Correlation","abstract":"ABSTRACT For cell instance segmentation on Electron Microscopy (EM) images, state-of-the-art methods either conduct pixel-wise classification or follow a detection and segmentation manner. However, both approaches suffer from the enormous cell instances of EM images where cells are tightly close to each other and show inconsistent morphological properties and/or homogeneous appearances. This fact can easily lead to over-segmentation and under-segmentation problems for model prediction, i.e ., falsely splitting and merging adjacent instances. In this paper, we propose a novel approach incorporating non-local correlation in the embedding space to make pixel features distinct or similar to their neighbors and thus address the over- and under-segmentation problems. We perform experiments on five different EM datasets where our proposed method yields better results than several strong baselines. More importantly, by using non-local correlation, we observe fewer false separations within one cell and fewer false fusions between cells.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":402626,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":286239,"name":"Jianfeng Cao","orcid":"0000-0002-7323-8875","position":1,"is_corresponding":false},{"id":1180113,"name":"Wei Wang","orcid":"0000-0002-3110-5767","position":2,"is_corresponding":false},{"id":306032,"name":"Dawen Cai","orcid":"0000-0003-4471-2061","position":3,"is_corresponding":false},{"id":1180114,"name":"Yan Yan","orcid":"0000-0003-4993-3621","position":4,"is_corresponding":false},{"id":367137,"name":"Bin Duan","orcid":"0000-0003-3302-1900","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T01:20:27.903246Z","pmid":"36747649","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}