{"doi":"10.1101/2023.01.19.524673","title":"Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody","abstract":"SUMMARY The structural and characteristic features of HIV-1 broadly neutralizing antibodies (bnAbs) from chronically infected pediatric donors are currently unknown. Herein, we characterized a heavy chain matured HIV-1 bnAb 44m, identified from a pediatric elite-neutralizer. Interestingly, in comparison to its wild-type AIIMS-P01 bnAb, 44m exhibited moderately higher level of somatic hypermutations of 15.2%. The 44m neutralized 79% of HIV-1 heterologous viruses (n=58) tested, with a geometric mean IC 50 titer of 0.36 µg/ml. The cryo-EM structure of 44m Fab in complex with fully-cleaved glycosylated native-like BG505.SOSIP.664.T332N gp140 envelope trimer at 4.4Å resolution revealed that 44m targets the V3-glycan N332-supersite and GDIR motif to neutralize HIV-1 with improved potency and breadth, plausibly attributed by a matured heavy chain as compared to that of wild-type AIIMS-P01. This study further improves our understanding on pediatric HIV-1 bnAbs and structural basis of broad HIV-1 neutralization by 44m may be useful blueprint for vaccine design in future.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2023,"id":395680,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":568803,"name":"Swarandeep Singh","orcid":"0000-0003-1186-1327","position":1,"is_corresponding":false},{"id":1134126,"name":"Arnab Chatterjee","orcid":"0000-0002-4089-8252","position":2,"is_corresponding":false},{"id":879805,"name":"Prashant Bajpai","orcid":"0000-0002-8443-9787","position":3,"is_corresponding":false},{"id":466216,"name":"Shaifali Sharma","orcid":"0000-0002-5751-2475","position":4,"is_corresponding":false},{"id":1134596,"name":"Sanket Katpara","orcid":null,"position":5,"is_corresponding":false},{"id":466222,"name":"Rakesh Lodha","orcid":"0000-0003-2608-1163","position":6,"is_corresponding":false},{"id":439803,"name":"Somnath Dutta","orcid":"0000-0002-3181-0108","position":7,"is_corresponding":false},{"id":345793,"name":"Kalpana Luthra","orcid":"0000-0002-7801-2867","position":8,"is_corresponding":false},{"id":466218,"name":"Sanjeev Kumar","orcid":"0000-0002-8181-3999","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T01:19:22.857556Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}