{"doi":"10.1101/2023.01.10.23284370","title":"Non-invasive thoracoabdominal mapping of post-oesophagectomy conduit function","abstract":"Abstract Introduction Oesophagectomy is a complex procedure performed for malignant and benign conditions. Post-oesophagectomy conduit dysfunction is common, which can occur for several reasons including conduit dysmotility. However, reliable tools for evaluating conduit motility are lacking. A non-invasive device for gastric electrical mapping was recently developed to evaluate gastric electrical activity and function. This study aimed to assess the feasibility of BSGM in the post-oesophagectomy stomach. Methods Oesophagectomy patients from Auckland, New Zealand, were recruited. The Gastric Alimetry System® (New Zealand) was employed, comprising a stretchable array (8×8 electrodes), a wearable Reader, and validated iOS app for symptom logging. The protocol comprised a 30-minute baseline, a meal challenge, then 4 hours of post-prandial recordings. Analysis encompassed Principal Gastric Frequency, BMI-adjusted amplitude, Gastric Alimetry Rhythm Index (indicating rhythm stability), meal response, and symptoms. Adverse events were recorded. Results 6 patients were recruited and gastric activity was successfully captured in all except one with the colonic interposition (negative control). Four patients showed abnormalities indicating post-operative gastric hypofunction: four with low or abnormal frequency (<2.65 cycles/min), three with low amplitude (<22μV), two with low GA-RI (<0.25) and one with a reduced meal response. One patient had significant symptoms (nausea, early satiation) who demonstrated marked hypomotility in all four of these domains. No adverse events occurred. Conclusion Gastric Alimetry is a safe and feasible technique to non-invasively assess gastric conduit motility following oesophagectomy. Parameters may need adjustment for post-surgical anatomy. Clinical studies assessing the role in diagnosis and therapy can be advanced.","journal":"medRxiv","year":2023,"id":394026,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1069100,"name":"Ashraf Tokhi","orcid":null,"position":1,"is_corresponding":false},{"id":983599,"name":"Armen A. Gharibans","orcid":"0000-0002-9139-4740","position":2,"is_corresponding":false},{"id":1069101,"name":"Nicholas Evennett","orcid":null,"position":3,"is_corresponding":false},{"id":915927,"name":"Grant Beban","orcid":null,"position":4,"is_corresponding":false},{"id":449383,"name":"Gabriel Schamberg","orcid":"0000-0002-4188-9614","position":5,"is_corresponding":false},{"id":983592,"name":"Chris Varghese","orcid":"0000-0001-7369-8639","position":6,"is_corresponding":false},{"id":983593,"name":"Stefan Calder","orcid":"0000-0002-5855-1732","position":7,"is_corresponding":false},{"id":915930,"name":"Cuong Duong","orcid":null,"position":8,"is_corresponding":false},{"id":877023,"name":"Greg O’Grady","orcid":null,"position":9,"is_corresponding":false},{"id":1068537,"name":"Tim Hsu‐Han Wang","orcid":"0000-0001-6200-2384","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T01:19:10.334330Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}