{"doi":"10.1101/2022.12.25.521784","title":"A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates","abstract":"While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. Following a booster ∼one year after the initial immunization, DCFHP-alum elicits a robust anamnestic response. To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. DCFHP-alum has potential as a once-yearly booster vaccine, and as a primary vaccine for pediatric use including in infants.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":296897,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":14909,"name":"Mrinmoy Sanyal","orcid":"0000-0002-1365-4279","position":1,"is_corresponding":false},{"id":984903,"name":"Natalia Friedland","orcid":null,"position":2,"is_corresponding":false},{"id":552688,"name":"Shaogeng Tang","orcid":"0000-0002-3904-492X","position":3,"is_corresponding":false},{"id":106156,"name":"Prabhu S. Arunachalam","orcid":"0000-0003-0090-5689","position":4,"is_corresponding":false},{"id":805663,"name":"Mengyun Hu","orcid":"0000-0003-4495-7501","position":5,"is_corresponding":false},{"id":636808,"name":"Ozan S. Kumru","orcid":"0000-0002-5010-7223","position":6,"is_corresponding":false},{"id":615704,"name":"Mary Kate Morris","orcid":"0000-0003-0143-5615","position":7,"is_corresponding":false},{"id":615056,"name":"Jane Fontenot","orcid":"0000-0002-1846-7915","position":8,"is_corresponding":false},{"id":618115,"name":"Lisa Shirreff","orcid":"0000-0002-8403-451X","position":9,"is_corresponding":false},{"id":984904,"name":"Jonathan Do","orcid":null,"position":10,"is_corresponding":false},{"id":892262,"name":"Ya-Chen Cheng","orcid":null,"position":11,"is_corresponding":false},{"id":984905,"name":"Gayathri Vasudevan","orcid":null,"position":12,"is_corresponding":false},{"id":922548,"name":"Mark B. Feinberg","orcid":"0000-0003-1165-4328","position":13,"is_corresponding":false},{"id":258352,"name":"François Villinger","orcid":"0000-0002-7790-2008","position":14,"is_corresponding":false},{"id":555873,"name":"Carl V. Hanson","orcid":"0000-0001-9569-2932","position":15,"is_corresponding":false},{"id":446591,"name":"Sangeeta B. Joshi","orcid":null,"position":16,"is_corresponding":false},{"id":445966,"name":"David B. Volkin","orcid":"0000-0002-1448-1998","position":17,"is_corresponding":false},{"id":106177,"name":"Bali Pulendran","orcid":"0000-0001-6517-4333","position":18,"is_corresponding":false},{"id":226842,"name":"Peter S. Kim","orcid":"0000-0001-6503-4541","position":19,"is_corresponding":false},{"id":552689,"name":"Payton A. Weidenbacher","orcid":"0000-0002-7692-0458","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T00:31:21.257700Z","pmid":"36597527","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}