{"doi":"10.1101/2022.12.19.521083","title":"Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury","abstract":"Abstract The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing the formation of a C3 -expressing neuroinflammatory reactive astrocyte sub-state rescues myelination and behavioral deficits. We further demonstrate the presence of C3 -expressing reactive astrocytes in human WMI. Our data point to these cells as putative drivers of myelination failure in WMI and a potentially promising therapeutic target.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":302394,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9456,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":994406,"name":"Daniel Surbek","orcid":"0000-0001-7705-1584","position":1,"is_corresponding":false},{"id":994407,"name":"Valérie Haesler","orcid":"0000-0001-8470-0052","position":2,"is_corresponding":false},{"id":994408,"name":"Vera Tscherrig","orcid":"0000-0002-3601-5453","position":3,"is_corresponding":false},{"id":226820,"name":"Eric J. Huang","orcid":"0000-0002-5381-3801","position":4,"is_corresponding":false},{"id":731240,"name":"Manideep Chavali","orcid":"0000-0002-0580-103X","position":5,"is_corresponding":false},{"id":29917,"name":"Shane A. Liddelow","orcid":"0000-0002-0840-1437","position":6,"is_corresponding":false},{"id":57577,"name":"David H. Rowitch","orcid":"0000-0002-0079-0060","position":7,"is_corresponding":false},{"id":994409,"name":"Andreina Schoeberlein","orcid":"0000-0002-6716-9551","position":8,"is_corresponding":false},{"id":537934,"name":"Amanda Brosius Lutz","orcid":"0000-0001-6227-104X","position":9,"is_corresponding":false},{"id":994758,"name":"Patricia Renz","orcid":null,"position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T00:32:16.279991Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}