{"doi":"10.1101/2022.11.29.22282912","title":"The impact of assortative mating, participation bias, and socioeconomic status on the polygenic risk of behavioral and psychiatric traits","abstract":"Abstract To investigate assortative mating (AM), participation bias, and socioeconomic status (SES) with respect to the genetics of behavioral and psychiatric traits, we analyzed gametic phase disequilibrium (GPD), within-spouses and within-siblings polygenic risk score (PRS) correlation, performing a SES conditional analysis. We observed genetic signatures of AM across multiple methods for traits related to substance use with SES conditioning increasing the within-spouses PRS correlation for Frequency of drinking alcohol (2.5% to 6%), Maximum habitual alcohol intake (1.33% to 4.43%), and Ever taken cannabis (1.5% to 5.3%). Comparing UK Biobank mental health questionnaire responders vs. non-responders, major depressive disorder PRS showed significant GPD in both groups when based on the Million Veteran Program (3.2% vs. 3%), but only in responders when based on the Psychiatric Genomics Consortium (3.8% vs. 0.2%). These results highlight the impact of AM, participation bias, and SES on the polygenic risk of behavioral and psychiatric traits.","journal":"medRxiv","year":2022,"id":302241,"datarank":0.21693923265571036,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.052147389355493914,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.052147389355493914,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230694,"name":"Frank R. Wendt","orcid":"0000-0002-2108-6822","position":1,"is_corresponding":false},{"id":432396,"name":"Gita A. Pathak","orcid":"0000-0003-3943-0895","position":2,"is_corresponding":false},{"id":21726,"name":"Loïc Yengo","orcid":"0000-0002-4272-9305","position":3,"is_corresponding":false},{"id":229994,"name":"Renato Polimanti","orcid":"0000-0003-0745-6046","position":4,"is_corresponding":false},{"id":794130,"name":"Brenda Cabrera‐Mendoza","orcid":"0000-0003-4729-9997","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:32:16.279991Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}