{"doi":"10.1101/2022.11.23.517706","title":"Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer’s disease individuals","abstract":"Infection with the etiological agent of COVID-19, SARS-CoV-2, appears capable of impacting cognition, which some patients with Post-acute Sequelae of SARS-CoV-2 (PASC). To evaluate neuro-pathophysiological consequences of SARS-CoV-2 infection, we examine transcriptional and cellular signatures in the Broadman area 9 (BA9) of the frontal cortex and the hippocampal formation (HF) in SARS-CoV-2, Alzheimer's disease (AD) and SARS-CoV-2 infected AD individuals, compared to age- and gender-matched neurological cases. Here we show similar alterations of neuroinflammation and blood-brain barrier integrity in SARS-CoV-2, AD, and SARS-CoV-2 infected AD individuals. Distribution of microglial changes reflected by the increase of Iba-1 reveal nodular morphological alterations in SARS-CoV-2 infected AD individuals. Similarly, HIF-1α is significantly upregulated in the context of SARS-CoV-2 infection in the same brain regions regardless of AD status. The finding may help to inform decision-making regarding therapeutic treatments in patients with neuro-PASC, especially those at increased risk of developing AD. Teaser: SARS-CoV-2 and Alzheimer's disease share similar neuroinflammatory processes, which may help explain neuro-PASC.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":298925,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9496,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":471979,"name":"Kyle J. Trageser","orcid":"0000-0001-9161-0178","position":1,"is_corresponding":false},{"id":260583,"name":"Sean X. Naughton","orcid":"0000-0003-3807-9167","position":2,"is_corresponding":false},{"id":916925,"name":"Eun‐Jeong Yang","orcid":null,"position":3,"is_corresponding":false},{"id":902923,"name":"Brian Mathew","orcid":"0000-0002-7224-339X","position":4,"is_corresponding":false},{"id":988338,"name":"Grace Van Hyfte","orcid":"0009-0001-8791-2285","position":5,"is_corresponding":false},{"id":843373,"name":"Linh Hellmers","orcid":null,"position":6,"is_corresponding":false},{"id":3115,"name":"Nathalie Jetté","orcid":"0000-0003-1351-5866","position":7,"is_corresponding":false},{"id":653039,"name":"Molly Estill","orcid":"0009-0007-6322-6989","position":8,"is_corresponding":false},{"id":328296,"name":"Li Shen","orcid":"0000-0002-5190-2851","position":9,"is_corresponding":false},{"id":237298,"name":"Tracy Fischer","orcid":"0000-0003-4859-3776","position":10,"is_corresponding":false},{"id":260585,"name":"Giulio Maria Pasinetti","orcid":"0000-0002-1524-5196","position":11,"is_corresponding":false},{"id":916926,"name":"Elizabeth Griggs","orcid":null,"position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:40.528568Z","pmid":"36451886","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}