{"doi":"10.1101/2022.11.11.516163","title":"Mapping phosphorylation post-translational modifications along single peptides with nanopores","abstract":"Abstract Current methods to detect post-translational modifications (PTMs) of proteins, such as phosphate groups, cannot measure single molecules and often cannot differentiate between closely spaced phosphorylation sites. Using a nanopore sequencing approach, we here report detection of PTMs at the single-molecule level on immunopeptide sequences with cancer-associated phosphate variants. We reliably discriminate peptide sequences with one or two closely spaced phosphates with 95% accuracy for individual reads of single molecules.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":299610,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":989504,"name":"Justas Ritmejeris","orcid":"0000-0002-6166-4594","position":1,"is_corresponding":false},{"id":989505,"name":"Henry Brinkerhoff","orcid":"0000-0003-2735-8048","position":2,"is_corresponding":false},{"id":989506,"name":"Theo J. R. Koenig","orcid":"0000-0002-6141-0455","position":3,"is_corresponding":false},{"id":822403,"name":"Jens H. Gundlach","orcid":"0000-0002-0773-8038","position":4,"is_corresponding":false},{"id":618042,"name":"Cees Dekker","orcid":"0000-0001-6273-071X","position":5,"is_corresponding":false},{"id":989503,"name":"Ian C. Nova","orcid":"0000-0003-1070-942X","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T00:31:44.904250Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}