{"doi":"10.1101/2022.11.09.515832","title":"Helminth exposure protects against murine SARS-CoV-2 infection through macrophage dependent T cell activation","abstract":"Summary Helminth endemic regions report lower COVID-19 morbidity and mortality. Here, we show that lung remodeling from a prior infection with a lung migrating helminth, Nippostrongylus brasiliensis , enhances viral clearance and survival of human-ACE2 transgenic mice challenged with SARS-CoV-2 (SCV2). This protection is associated with a lymphocytic infiltrate including an increased accumulation of pulmonary SCV2-specific CD8+ T cells and anti-CD8 antibody depletion abrogated the N. brasiliensis -mediated reduction in viral loads. Pulmonary macrophages with a type-2 transcriptional signature persist in the lungs of N. brasiliensis exposed mice after clearance of the parasite and establish a primed environment for increased antigen presentation. Accordingly, depletion of macrophages ablated the augmented viral clearance and accumulation of CD8+ T cells driven by prior N. brasiliensis infection. Together, these findings support the concept that lung migrating helminths can limit disease severity during SCV2 infection through macrophage-dependent enhancement of anti-viral CD8+ T cell responses. Abstract Figure","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":299607,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":368727,"name":"Oyebola O. Oyesola","orcid":"0000-0002-5347-7502","position":1,"is_corresponding":false},{"id":479028,"name":"Sivaranjani Namasivayam","orcid":"0000-0001-9993-1347","position":2,"is_corresponding":false},{"id":989502,"name":"Nina Howard","orcid":"0000-0002-1204-5885","position":3,"is_corresponding":false},{"id":237971,"name":"Chad S. Clancy","orcid":"0000-0002-5354-9270","position":4,"is_corresponding":false},{"id":806503,"name":"Sandra D. Oland","orcid":"0000-0002-6544-5268","position":5,"is_corresponding":false},{"id":391925,"name":"Nicole L. Garza","orcid":null,"position":6,"is_corresponding":false},{"id":412160,"name":"Bernard A. P. Lafont","orcid":"0000-0003-2140-6205","position":7,"is_corresponding":false},{"id":232893,"name":"Reed F. Johnson","orcid":"0000-0002-4312-0550","position":8,"is_corresponding":false},{"id":278223,"name":"Katrin D. Mayer-Barber","orcid":"0000-0002-0311-3233","position":9,"is_corresponding":false},{"id":330710,"name":"Alan Sher","orcid":"0000-0001-7053-2895","position":10,"is_corresponding":false},{"id":253555,"name":"P’ng Loke","orcid":"0000-0002-6211-3292","position":11,"is_corresponding":false},{"id":486816,"name":"Kerry L. Hilligan","orcid":"0000-0003-1238-1552","position":0,"is_corresponding":true}],"reference_count":93,"raw_metadata":null,"created_at":"2026-07-19T00:31:44.904250Z","pmid":"36380767","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}