{"doi":"10.1101/2022.10.20.512802","title":"Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex","abstract":"ABSTRACT Recent work has demonstrated that the relationship between structural and functional connectivity varies regionally across the human brain, with reduced coupling emerging along the sensory-association cortical hierarchy. The biological underpinnings driving this expression, however, remain largely unknown. Here, we postulated that intracortical myelination and excitation-inhibition (EI) balance mediate the heterogeneous expression of structure-function coupling (SFC) and its temporal variance across the cortical hierarchy. We employed atlas-and voxel-based connectivity approaches to analyze neuroimaging data acquired from two groups of healthy participants. Our findings were consistent across processing pipelines: 1) increased myelination and lower EI-ratio associated with more rigid SFC and restricted moment-to-moment SFC fluctuations; 2) a gradual shift from EI-ratio to myelination as the principal predictor of SFC occurred when traversing from granular to agranular cortical regions. Collectively, our work delivers a novel framework to conceptualize structure-function relationships in the human brain, paving the way for an improved understanding of how demyelination and/or EI-imbalances induce reorganization in brain disorders.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":297579,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":285909,"name":"Matthew Cieslak","orcid":"0000-0002-1931-4734","position":1,"is_corresponding":false},{"id":285825,"name":"Xiaosong He","orcid":"0000-0002-7941-2918","position":2,"is_corresponding":false},{"id":699104,"name":"Lorenzo Caciagli","orcid":"0000-0001-7189-9699","position":3,"is_corresponding":false},{"id":985678,"name":"Mathieu Ouellet","orcid":"0000-0002-0651-4817","position":4,"is_corresponding":false},{"id":230040,"name":"Theodore D. Satterthwaite","orcid":"0000-0001-7072-9399","position":5,"is_corresponding":false},{"id":52271,"name":"Russell T. Shinohara","orcid":"0000-0001-8627-8203","position":6,"is_corresponding":false},{"id":645398,"name":"Dani S. Bassett","orcid":null,"position":7,"is_corresponding":false},{"id":452581,"name":"Panagiotis Fotiadis","orcid":"0000-0001-7287-9227","position":0,"is_corresponding":true}],"reference_count":109,"raw_metadata":null,"created_at":"2026-07-19T00:31:26.161109Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}