{"doi":"10.1101/2022.10.12.22280855","title":"Background prostate tissue is quantitatively abnormal on MRI in patients with clinically significant prostate cancer","abstract":"Abstract Background T 2 -weighted MRI is standard for detecting clinically significant prostate cancer (csPCa) by identifying visible lesions that stand out from the background prostate. Purpose To determine whether patients with csPCa have abnormal T 2 -weighted signal in non-lesion, background prostate tissue (BP). Methods This retrospective study included two patient cohorts who underwent 3T MRI examination for suspected csPCa. Median (urine-normalized) T 2 -weighted signal was computed for BP and compared between patients with and without csPCa. csPCa discrimination performance of T 2 -weighted BP signal was evaluated using area under receiver operating characteristic curves (AUC). T 2 and S 0 (a proxy for proton density) were computed and compared between patients with and without csPCa. T 2 was also recomputed using larger buffers around csPCa lesions. csPCa discrimination performance was compared between two predictors: Restriction Spectrum Imaging (RSI) C 1 and RSI C 1 normalized by global prostate median T 2 -weighted signal. Results Cohort 1: 46 patients (age: 64±10 years). Cohort 2: 151 patients (65±8 years). Urine-normalized T 2 -weighted signal was systematically lower in BP of subjects with csPCa ( p ≤0.034) and indicated the presence of cancer (cohort 1: AUC=0.80; cohort 2: AUC=0.68). BP T 2 was significantly lower in csPCa patients ( p ≤0.011), while S 0 was not ( p ≥0.30). BP T 2 measurements were stable to within 5% with buffers from 0 to 30 mm around visible lesions. csPCa discrimination improved with incorporation of BP T 2 -weighted signal (cohort 1: AUC=0.72 for RSI C 1 alone, versus 0.81 with BP T 2 -weighted signal; cohort 2: AUC=0.63 versus 0.76). Conclusion Lower T 2 -weighted signal in BP suggests the presence of csPCa.","journal":"medRxiv","year":2022,"id":302021,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7574,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":329263,"name":"Roshan Karunamuni","orcid":"0000-0001-6918-0589","position":1,"is_corresponding":false},{"id":875622,"name":"Troy S. Hussain","orcid":null,"position":2,"is_corresponding":false},{"id":874973,"name":"Allison Y. Zhong","orcid":"0000-0001-5732-1380","position":3,"is_corresponding":false},{"id":987511,"name":"Karoline Kallis","orcid":"0000-0002-0889-004X","position":4,"is_corresponding":false},{"id":987895,"name":"D. Deondre","orcid":null,"position":5,"is_corresponding":false},{"id":691067,"name":"Asona Lui","orcid":"0000-0002-0076-3492","position":6,"is_corresponding":false},{"id":994053,"name":"Garnier Mani","orcid":null,"position":7,"is_corresponding":false},{"id":994054,"name":"Courtney Ollison","orcid":null,"position":8,"is_corresponding":false},{"id":993569,"name":"Mariluz Rojo Domingo","orcid":"0000-0003-1386-4636","position":9,"is_corresponding":false},{"id":993570,"name":"Ahmed Shabaik","orcid":"0000-0003-1987-3453","position":10,"is_corresponding":false},{"id":325363,"name":"Christopher J. Kane","orcid":"0000-0002-8769-2112","position":11,"is_corresponding":false},{"id":345891,"name":"Aditya Bagrodia","orcid":"0000-0002-3358-1193","position":12,"is_corresponding":false},{"id":105165,"name":"Rana R. McKay","orcid":"0000-0002-0581-7963","position":13,"is_corresponding":false},{"id":360590,"name":"Joshua Kuperman","orcid":"0000-0002-7890-4785","position":14,"is_corresponding":false},{"id":360597,"name":"Rebecca Rakow‐Penner","orcid":"0000-0002-2566-1978","position":15,"is_corresponding":false},{"id":360593,"name":"Michael E. Hahn","orcid":"0000-0002-8323-8174","position":16,"is_corresponding":false},{"id":19608,"name":"Anders M. Dale","orcid":"0000-0002-6126-2966","position":17,"is_corresponding":false},{"id":360589,"name":"Tyler M. Seibert","orcid":"0000-0002-4089-7399","position":18,"is_corresponding":false},{"id":360587,"name":"Christopher C. Conlin","orcid":"0000-0003-4509-8702","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:32:06.309890Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}