{"doi":"10.1101/2022.10.01.510445","title":"Memory CD4 T cell subset organization in the female reproductive tract is regulated via the menstrual cycle through CCR5 signaling","abstract":"Abstract Despite their importance for immunity against sexually transmitted infections (STIs), the composition of the female reproductive tract (FRT) memory CD4 T cell population in response to changes in the local tissue environment during the menstrual cycle remains poorly defined. Here we show that across humans, non-human primates (NHP), and mice, FRT CD4 T cells comprise distinct subsets corresponding to migratory memory (T MM ) and resident memory (T RM ) cells. T MM display tissue-itinerant trafficking characteristics, restricted FRT tissue distribution, with distinct transcriptional properties and effector responses to infection. CD4 T cell subset fluctuations synchronized with cycle-driven proinflammatory changes within the local tissue environment and oral administration of a CCR5 antagonist inhibited cycle phase-specific migratory T cell surveillance. This study provides novel insights into the dynamic nature of FRT memory CD4 T cells and identifies the menstrual cycle as a key regulator of memory T cell defense at the site of STI exposure. Summary The menstrual cycle regulates memory T cell surveillance.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":312101,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":280878,"name":"Alexander N. Wein","orcid":"0000-0002-8813-3523","position":1,"is_corresponding":false},{"id":1009580,"name":"Felica P. Hardnett","orcid":null,"position":2,"is_corresponding":false},{"id":301948,"name":"Anandi N. Sheth","orcid":"0000-0002-6305-2727","position":3,"is_corresponding":false},{"id":262574,"name":"Zheng-Rong Tiger Li","orcid":"0000-0003-0524-279X","position":4,"is_corresponding":false},{"id":799705,"name":"Michelle Williams","orcid":"0000-0001-9390-9165","position":5,"is_corresponding":false},{"id":1008399,"name":"Jessica Radzio‐Basu","orcid":"0000-0002-0395-0736","position":6,"is_corresponding":false},{"id":492248,"name":"Huiyuan Zheng","orcid":"0000-0002-5214-0043","position":7,"is_corresponding":false},{"id":341005,"name":"Chuong Dinh","orcid":null,"position":8,"is_corresponding":false},{"id":342211,"name":"Lisa B. Haddad","orcid":"0000-0002-7631-6760","position":9,"is_corresponding":false},{"id":1009581,"name":"Elizabeth M.B. Collins","orcid":null,"position":10,"is_corresponding":false},{"id":232938,"name":"Jenna L Lobby","orcid":"0000-0002-1395-2583","position":11,"is_corresponding":false},{"id":1009582,"name":"Kirsten Kost","orcid":null,"position":12,"is_corresponding":false},{"id":275696,"name":"Sarah L. Hayward","orcid":"0000-0001-7052-5556","position":13,"is_corresponding":false},{"id":382869,"name":"Igho Ofotokun","orcid":"0000-0003-2735-1903","position":14,"is_corresponding":false},{"id":425963,"name":"Rustom Antia","orcid":"0000-0001-7991-614X","position":15,"is_corresponding":false},{"id":270265,"name":"Christopher D. Scharer","orcid":"0000-0001-7716-8504","position":16,"is_corresponding":false},{"id":232940,"name":"Anice C. Lowen","orcid":"0000-0002-9829-112X","position":17,"is_corresponding":false},{"id":340074,"name":"J. Gerardo Garcı́a-Lerma","orcid":"0000-0001-6437-7745","position":18,"is_corresponding":false},{"id":232939,"name":"Jacob E. Kohlmeier","orcid":"0000-0002-7209-6641","position":19,"is_corresponding":false},{"id":737152,"name":"Alison Swaims-Kohlmeier","orcid":"0000-0001-6508-0038","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:33:32.327694Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}