{"doi":"10.1101/2022.09.28.509817","title":"Low-dimensional organization of global brain states of reduced consciousness","abstract":"Abstract Brain states are frequently represented using a unidimensional scale measuring the richness of subjective experience (level of consciousness). This description assumes a mapping between the high-dimensional space of whole-brain configurations and the trajectories of brain states associated with changes in consciousness, yet this mapping and its properties remain unknown. We combined whole-brain modelling, data augmentation and deep learning for dimensionality reduction to determine a mapping representing states of consciousness in a low-dimensional space, where distances parallel similarities between states. An orderly trajectory from wakefulness to brain injured patients is revealed in a latent space whose coordinates represent metrics related to functional modularity and structure-function coupling, both increasing alongside loss of consciousness. Finally, we investigated the effects of model perturbations, providing geometrical interpretation for the stability and reversibility of states. We conclude that conscious awareness depends on functional patterns encoded as a low-dimensional trajectory within the vast space of brain configurations.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":299519,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.606,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":557840,"name":"Carla Pallavicini","orcid":"0000-0001-9589-7735","position":1,"is_corresponding":false},{"id":989897,"name":"Juan Piccinini","orcid":null,"position":2,"is_corresponding":false},{"id":557842,"name":"Athéna Demertzi","orcid":"0000-0001-8021-3759","position":3,"is_corresponding":false},{"id":557843,"name":"Vincent Bonhomme","orcid":"0000-0001-6356-547X","position":4,"is_corresponding":false},{"id":557844,"name":"Charlotte Martial","orcid":"0000-0001-6291-3460","position":5,"is_corresponding":false},{"id":557845,"name":"Rajanikant Panda","orcid":"0000-0002-0960-4340","position":6,"is_corresponding":false},{"id":989408,"name":"Naji Alnagger","orcid":"0000-0002-7880-6237","position":7,"is_corresponding":false},{"id":557846,"name":"Jitka Annen","orcid":"0000-0002-7459-4345","position":8,"is_corresponding":false},{"id":278360,"name":"Olivia Gosseries","orcid":"0000-0001-9011-7496","position":9,"is_corresponding":false},{"id":282310,"name":"Agustín Ibáñez","orcid":"0000-0001-6758-5101","position":10,"is_corresponding":false},{"id":324029,"name":"Helmut Laufs","orcid":"0000-0003-0030-2781","position":11,"is_corresponding":false},{"id":245933,"name":"Jacobo Sitt","orcid":"0000-0002-3878-4846","position":12,"is_corresponding":false},{"id":255543,"name":"Viktor Jirsa","orcid":"0000-0002-8251-8860","position":13,"is_corresponding":false},{"id":989898,"name":"Morten Kringelbach","orcid":null,"position":14,"is_corresponding":false},{"id":245927,"name":"Steven Laureys","orcid":"0000-0002-3096-3807","position":15,"is_corresponding":false},{"id":557847,"name":"Gustavo Deco","orcid":"0000-0002-8995-7583","position":16,"is_corresponding":false},{"id":315384,"name":"Enzo Tagliazucchi","orcid":"0000-0003-0421-9993","position":17,"is_corresponding":false},{"id":308096,"name":"Yonatan Sanz Perl","orcid":"0000-0002-1270-5564","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T00:31:44.904250Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}