{"doi":"10.1101/2022.09.27.509745","title":"Control of lipolysis by a population of oxytocinergic sympathetic neurons","abstract":"Oxytocin (OXT), a nine amino acid peptide produced in the hypothalamus and released by the posterior pituitary, has well-known actions in parturition, lactation, and social behavior 1 , and has become an intriguing therapeutic target for diseases like autism and schizophrenia 2 . Exogenous OXT has also been shown to promote weight loss, among other beneficial metabolic effects 1,3 , suggesting that its therapeutic potential may extend to diabetes and obesity 1,4 . It is unclear, however, whether endogenous OXT participates in metabolic homeostasis. Here we show that OXT is a critical regulator of adipose tissue lipolysis in both mice and humans. In addition, OXT serves to license the ability of β- adrenergic agonists to fully promote lipolysis. Most surprisingly, the relevant source of OXT in these metabolic actions is a previously unidentified subpopulation of tyrosine hydroxylase (TH)-positive sympathetic neurons. Our data reveal that OXT from the peripheral nervous system is an endogenous regulator of adipose and systemic metabolism.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":300472,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":650014,"name":"Luhong Wang","orcid":"0000-0002-1085-841X","position":1,"is_corresponding":false},{"id":71312,"name":"Daqing Wang","orcid":"0000-0002-7134-3065","position":2,"is_corresponding":false},{"id":292013,"name":"Jingyi Chi","orcid":"0000-0001-6013-8544","position":3,"is_corresponding":false},{"id":267703,"name":"Gordon I. Smith","orcid":"0000-0003-0063-046X","position":4,"is_corresponding":false},{"id":990963,"name":"Samuel Klein","orcid":"0000-0001-5786-7113","position":5,"is_corresponding":false},{"id":292019,"name":"Paul Cohen","orcid":"0000-0002-2786-8585","position":6,"is_corresponding":false},{"id":51619,"name":"Evan D. Rosen","orcid":"0000-0003-4603-708X","position":7,"is_corresponding":false},{"id":650747,"name":"Erwei Li","orcid":null,"position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:53.559757Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}