{"doi":"10.1101/2022.09.22.22280180","title":"A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA (BNT162b2/mRNA-1273) and adenovirus vectored vaccines (ChAdOx1-S) after the first, second and third doses","abstract":"Abstract We longitudinally profiled immune responses in 102 adults who received BNT162b2 (Pfizer-BioNTech) or ChAdOx1-S (Oxford-AstraZeneca) as their primary vaccinations. Bloods were collected pre-vaccination, 1-7 days after the 1 st , 2 nd and 3 rd doses (BNT162b2 or mRNA-1273) to assess innate and early adaptive responses, and ∼28 days after the 2 nd and 3 rd doses to assess immunogenicity. Using a multi-omics approach including RNAseq, cytokine multiplex assay, proteomics, lipidomics, and flow cytometry we identified key differences in the immune responses induced by the ChAdOx1-S and BNT162b2 vaccines that were correlated with subsequent antigen-specific antibody and T cell responses or vaccine reactogenicity. We observed that vaccination with ChAdOx1-S but not BNT162b2 induced a memory-like response after the first dose, which was correlated with the expression of several proteins involved in complement and coagulation. The COVID-19 Vaccine Immune Responses Study (COVIRS) thus represents a major resource to understand the immunogenicity and reactogenicity of these COVID-19 vaccines.","journal":"medRxiv","year":2022,"id":304364,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9298,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":997189,"name":"Todd S. 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Masavuli","orcid":"0000-0001-7287-6595","position":9,"is_corresponding":false},{"id":831428,"name":"Arthur Eng Lip Yeow","orcid":"0000-0003-1282-5635","position":10,"is_corresponding":false},{"id":831430,"name":"Arunasingam Abayasingam","orcid":"0000-0002-9406-3058","position":11,"is_corresponding":false},{"id":831431,"name":"David Agapiou","orcid":"0000-0003-3913-3751","position":12,"is_corresponding":false},{"id":997196,"name":"Hannah Stevens","orcid":"0000-0003-3394-9768","position":13,"is_corresponding":false},{"id":997197,"name":"Jana Zecha","orcid":"0000-0002-8767-6294","position":14,"is_corresponding":false},{"id":997198,"name":"Nicole L. 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