{"doi":"10.1101/2022.09.16.508339","title":"Identification of a self-renewing muscle satellite cell state by single-cell chromatin accessibility profiling","abstract":"ABSTRACT A balance between self-renewal and differentiation is critical for the regenerative capacity of tissue-resident stem cells. In skeletal muscle, successful regeneration requires the orchestrated activation, proliferation, and differentiation of muscle satellite cells (MuSCs) that are normally quiescent. A subset of MuSCs undergoes self-renewal to replenish the stem cell pool, but the features that identify and define self-renewing MuSCs remain to be elucidate. Here, through single-cell chromatin accessibility analysis, we reveal the self-renewal versus differentiation trajectories of MuSCs over the course of regeneration in vivo. We identify TGFBR3 as a unique marker of self-renewing MuSCs that can be purified and efficiently contribute to regeneration after transplantation; and we show that SMAD4 and its downstream genes are genetically required for self-renewal in vivo by restricting differentiation. Our study unveils the identity and mechanisms of self-renewing MuSCs, while providing a key resource for comprehensive analysis of muscle regeneration.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":311417,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":558588,"name":"Xin Lin","orcid":"0000-0003-1376-3456","position":1,"is_corresponding":false},{"id":1007643,"name":"Chenghao Situ","orcid":"0000-0002-0637-0323","position":2,"is_corresponding":false},{"id":559681,"name":"Xiaolin Wei","orcid":null,"position":3,"is_corresponding":false},{"id":556184,"name":"Xiuqing Wei","orcid":"0000-0002-2034-6928","position":4,"is_corresponding":false},{"id":1007644,"name":"Zhenguo Wu","orcid":"0000-0003-3049-8324","position":5,"is_corresponding":false},{"id":249984,"name":"Yarui Diao","orcid":"0000-0001-5842-4082","position":6,"is_corresponding":false},{"id":806996,"name":"Arinze E. Okafor","orcid":"0000-0002-3416-1350","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:33:28.480200Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}