{"doi":"10.1101/2022.09.10.507437","title":"Enhancing adoptive T cell therapy with synergistic host immune engagement promotes long-term protection against solid tumors","abstract":"Abstract Adoptive T cell therapy provides the T cell pool needed for immediate tumor debulking, but the infused T cells generally have a narrow repertoire for antigen recognition and limited ability for long-term protection. Here, we present a biomaterial platform that enhances adoptive T cell therapy by synergistically engaging the host immune system via in-situ antigen-free vaccination. T cells alone loaded into these localized cell depots provided significantly better control of subcutaneous B16-F10 tumors than T cells delivered through direct peritumoral injection or intravenous infusion. The anti-tumor response was significantly enhanced when T cell delivery was combined with biomaterial-driven accumulation and activation of host immune cells, as this prolonged the activation state of the delivered T cells, minimized host T cell exhaustion, and enabled long-term tumor control. This integrated approach provides both immediate tumor debulking and long-term protection against solid tumors, including against tumor antigen escape.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":304264,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9485,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":313819,"name":"Joshua M. Brockman","orcid":"0000-0003-2775-3478","position":1,"is_corresponding":false},{"id":852416,"name":"Yutong Liu","orcid":"0000-0001-5683-5451","position":2,"is_corresponding":false},{"id":250232,"name":"David Zhang","orcid":"0000-0002-6999-6454","position":3,"is_corresponding":false},{"id":253886,"name":"Alexander J. Najibi","orcid":"0000-0001-7761-392X","position":4,"is_corresponding":false},{"id":461173,"name":"Alexander Stafford","orcid":"0000-0003-4739-8346","position":5,"is_corresponding":false},{"id":252880,"name":"Miguel C. Sobral","orcid":null,"position":6,"is_corresponding":false},{"id":997075,"name":"Yoav Binenbaum","orcid":"0000-0001-9901-7782","position":7,"is_corresponding":false},{"id":250234,"name":"Maxence O. Dellacherie","orcid":"0000-0002-2971-2381","position":8,"is_corresponding":false},{"id":65893,"name":"David Mooney","orcid":"0000-0001-6299-1194","position":9,"is_corresponding":false},{"id":843852,"name":"Kwasi Adu‐Berchie","orcid":"0000-0002-1959-6794","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:32:32.651796Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}