{"doi":"10.1101/2022.09.09.507294","title":"A novel overlapping gene <i>azyx-1</i> affects the translation of zyxin in <i>C. elegans</i>","abstract":"Abstract Overlapping genes are widely prevalent, however, their expression and consequences are poorly understood. Here, we describe and functionally characterize a novel zyx-1 overlapping gene, azyx-1 , with distinct regulatory functions in C. elegans . We observed conservation of alternative open reading frames overlapping the 5’ region of zyxin family members in several animal species, and find shared sites of azyx-1 and zyxin proteoform expression in C. elegans . In line with a standard ribosome scanning model, our results support cis regulation of zyx-1 long isoform(s) by upstream initiating azyx-1a . Moreover, we report on a rare observation of trans regulation of zyx-1 by azyx-1 , with evidence of increased ZYX-1 upon azyx-1 overexpression. Our results suggest a dual role for azyx-1 in influencing zyx-1 proteoform heterogeneity and highlights its impact on C. elegans muscular integrity and locomotion.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":311307,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9588,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1007543,"name":"Ellen Geens","orcid":"0000-0001-6117-2648","position":1,"is_corresponding":false},{"id":325285,"name":"Elke Vandewyer","orcid":"0000-0003-1774-1764","position":2,"is_corresponding":false},{"id":465991,"name":"Amanda Kieswetter","orcid":"0000-0001-6912-2987","position":3,"is_corresponding":false},{"id":626585,"name":"Christina Ludwig","orcid":"0000-0002-6131-7322","position":4,"is_corresponding":false},{"id":408779,"name":"Liesbet Temmerman","orcid":"0000-0002-1249-3995","position":5,"is_corresponding":false},{"id":778318,"name":"Bhavesh S. Parmar","orcid":"0000-0003-2005-8077","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:33:28.480200Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}