{"doi":"10.1101/2022.08.31.506047","title":"Comparative genomic and metagenomic investigations of the <i>Corynebacterium tuberculostearicum</i> species complex reveals potential mechanisms underlying associations to skin health and disease","abstract":"ABSTRACT Corynebacterium are a diverse genus and dominant member of the human skin microbiome. Recently, we reported that the most prevalent Corynebacterium species found on skin – including Corynebacterium tuberculostearicum and Corynebacterium kefirresidentii – comprise a narrow species complex despite the diversity of the genus. Here, we apply high-resolution phylogenomics and comparative genomics to describe the structure of the C. tuberculostearicum species complex. We find this species complex is missing a fatty acid biosynthesis gene family which is often found in multi-copy in approximately 99% of other Corynebacterium species. Conversely, this species complex is enriched for multiple genetic traits, including a gene encoding for a collagen-like peptide. Further, through metagenomic investigations, we find that one species within the complex, C. kefirresidentii , increases in relative abundance during atopic dermatitis flares and show that most members of this species possess a colocalized set of putative virulence genes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":301789,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9435,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":989046,"name":"Mary Hannah Swaney","orcid":"0000-0003-4039-6970","position":1,"is_corresponding":false},{"id":256615,"name":"Lindsay Kalan","orcid":"0000-0003-4980-5128","position":2,"is_corresponding":false},{"id":333414,"name":"Rauf Salamzade","orcid":"0000-0002-1923-5948","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T00:32:06.309890Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}