{"doi":"10.1101/2022.08.19.504399","title":"The CD103-XCR1 axis mediates the recruitment of immunoregulatory dendritic cells after traumatic injury","abstract":"ABSTRACT During wounding and material implantation there is a disturbance in tissue homeostasis and release of self-antigen, and regulation between tolerance and auto-inflammation in injury is not well understood. Here, we analyzed antigen-presenting cells in biomaterial-treated muscle injury and found that pro-regenerative materials enrich Batf3-dependent CD103 + XCR1 + CD301b + dendritic cells associated with cross-presentation and self-tolerance. Muscle trauma was accompanied by CD8 + iTregs and expansion of CD103 + XCR1 + CD62L - adaptive immune cells. Up-regulation of E-Cadherin (the ligand for CD103) and XCL-1 in injured tissue suggests a mechanism for cell recruitment to trauma. Without cross-presenting cells T cell activation increases, pro-regenerative macrophage polarization decreases, and muscle healing is impaired. These data describe a regulatory communication network through CD103 + XCR1 + immune cells resulting in downstream effects on tissue regeneration.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":300399,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":629704,"name":"Tran B. Ngo","orcid":"0000-0002-4093-7004","position":1,"is_corresponding":false},{"id":962550,"name":"Sabrina DeStefano","orcid":"0000-0003-4946-0422","position":2,"is_corresponding":false},{"id":629705,"name":"Kenneth M. Adusei","orcid":"0000-0002-9539-1387","position":3,"is_corresponding":false},{"id":990870,"name":"Minhaj Bhuiyan","orcid":"0009-0002-4813-0632","position":4,"is_corresponding":false},{"id":337672,"name":"Aditya Josyula","orcid":"0000-0002-1184-0481","position":5,"is_corresponding":false},{"id":990871,"name":"Mondreakest Faust","orcid":"0009-0002-7821-2284","position":6,"is_corresponding":false},{"id":109804,"name":"Aaron E. Lin","orcid":"0000-0001-7400-4125","position":7,"is_corresponding":false},{"id":629706,"name":"Maria Karkanitsa","orcid":"0000-0003-3474-2371","position":8,"is_corresponding":false},{"id":414605,"name":"Parinaz Fathi","orcid":"0000-0003-1639-5687","position":9,"is_corresponding":false},{"id":238245,"name":"Kaitlyn Sadtler","orcid":"0000-0003-2587-8330","position":10,"is_corresponding":false},{"id":629714,"name":"Ravi Lokwani","orcid":"0000-0002-6038-7150","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T00:31:53.559757Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}