{"doi":"10.1101/2022.08.14.503921","title":"Evasion of Neutralizing Antibody Response by the SARS-CoV-2 BA.2.75 Variant","abstract":"The newly emerged BA.2.75 SARS-CoV-2 variant exhibits an alarming 9 additional mutations in its spike (S) protein compared to the ancestral BA.2 variant. Here we examine the neutralizing antibody escape of BA.2.75 in mRNA-vaccinated and BA.1-infected individuals, as well as the molecular basis underlying functional changes in the S protein. Notably, BA.2.75 exhibits enhanced neutralization resistance over BA.2, but less than the BA.4/5 variant. The G446S and N460K mutations of BA.2.75 are primarily responsible for its enhanced resistance to neutralizing antibodies. The R493Q mutation, a reversion to the prototype sequence, reduces BA.2.75 neutralization resistance. The mutational impact is consistent with their locations in common neutralizing antibody epitopes. Further, the BA.2.75 variant shows enhanced cell-cell fusion over BA.2, driven largely by the N460K mutation, which enhances S processing. Structural modeling revealed a new receptor contact introduced by N460K, supporting a mechanism of potentiated receptor utilization and syncytia formation.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":297404,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":278003,"name":"John P. Evans","orcid":"0000-0001-8644-5825","position":1,"is_corresponding":false},{"id":278006,"name":"Yi-Min Zheng","orcid":"0000-0002-0394-9735","position":2,"is_corresponding":false},{"id":243261,"name":"Claire Carlin","orcid":"0000-0002-8344-0575","position":3,"is_corresponding":false},{"id":227281,"name":"Linda J. Saif","orcid":"0000-0002-3224-9009","position":4,"is_corresponding":false},{"id":244459,"name":"Eugene M. Oltz","orcid":"0000-0002-2513-7156","position":5,"is_corresponding":false},{"id":323756,"name":"Kai Xu","orcid":"0000-0001-5412-6942","position":6,"is_corresponding":false},{"id":629721,"name":"Richard J. Gumina","orcid":"0000-0001-8298-1129","position":7,"is_corresponding":false},{"id":278009,"name":"Shan‐Lu Liu","orcid":"0000-0003-1620-3817","position":8,"is_corresponding":false},{"id":278005,"name":"Panke Qu","orcid":"0000-0002-0222-365X","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T00:31:26.161109Z","pmid":"36032970","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}