{"doi":"10.1101/2022.08.10.503527","title":"A lone spike in blood glucose can enhance the thrombo-inflammatory response in cortical vessels","abstract":"ABSTRACT How transient hyperglycemia contributes to cerebro-vascular disease has been a challenge to study under controlled conditions. We present an approach to model luminal vessel thrombo-inflammation using amplified, ultrashort laser-pulses to physically disrupt brain-venule endothelium. Vessel disruption in conjunction with transient hyperglycemia from a single injection of metabolically active D -glucose results in real-time responses to venule damage that include rapid serum extravasation, platelet aggregation, and neutrophil recruitment, in normal mice. In contrast, vessel thrombo-inflammation following laser-induced vessel disruption is significantly reduced in mice injected with metabolically inert L-glucose. Thrombo-inflammation is pharmacologically ameliorated by a platelet inhibitor, by a scavenger of reactive oxygen species, or by a nitric oxide donor. For comparison, in diabetic mice injured vessel thrombo-inflammatory responses are also reduced by restoration of normo-glycemia. Our approach provides a controlled method to probe synergies of transient metabolic and physical vascular perturbations and reveals new aspects of brain pathophysiology.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":310641,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":74200,"name":"Conrad Foo","orcid":"0000-0002-1333-3678","position":1,"is_corresponding":false},{"id":628635,"name":"Rui Liu","orcid":"0000-0002-3634-0344","position":2,"is_corresponding":false},{"id":1006690,"name":"Yingying Cui","orcid":"0000-0003-0037-1664","position":3,"is_corresponding":false},{"id":628633,"name":"Xiang Ji","orcid":"0000-0001-8595-6009","position":4,"is_corresponding":false},{"id":776400,"name":"Thomas Broggini","orcid":"0000-0002-3733-486X","position":5,"is_corresponding":false},{"id":776399,"name":"Philipp Mächler","orcid":"0000-0001-7996-7684","position":6,"is_corresponding":false},{"id":369012,"name":"Prithu Sundd","orcid":"0000-0001-7568-5719","position":7,"is_corresponding":false},{"id":246429,"name":"Anna Devor","orcid":"0000-0002-5143-3960","position":8,"is_corresponding":false},{"id":629530,"name":"Beth Friedman","orcid":null,"position":9,"is_corresponding":false},{"id":227038,"name":"David Kleinfeld","orcid":"0000-0001-9797-4722","position":10,"is_corresponding":false},{"id":713879,"name":"Iftach Shaked","orcid":"0000-0002-5260-5912","position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-19T00:33:24.451129Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}