{"doi":"10.1101/2022.08.05.22278436","title":"A sagittal gradient of pathological and compensatory effects of neurophysiological slowing in Parkinson’s disease","abstract":"Abstract Using magnetoencephalographic imaging and extensive clinical and neuropsychological assessments, we show that patients with Parkinson’s disease (PD; N = 79) exhibit a slowing of neurophysiological activity relative to healthy adults (N = 65), which relates to motor and cognitive abilities. Importantly, the association between neurophysiological slowing and PD clinical features varies systematically across the cortex along a sagittal gradient: cortical slowing is associated with worse impairment in dorsal-posterior cortices, and this association is reversed in ventral-anterior cortical regions. This pathological-to- compensatory anatomical gradient is sensitive to differences in patients’ individual clinical profiles, and co- localizes with normative atlases of neurotransmitter receptor/transporter density. Long-range functional connectivity between posterior regions and parietal and frontal cortices is also significantly shifted towards lower frequencies in PD, demonstrating a novel network-level slowing effect. Taken together, these findings demonstrate the multifaceted nature of neurophysiological slowing in patients with PD, with anatomically-dependent clinical relevance to motor and cognitive symptoms.","journal":"medRxiv","year":2022,"id":297747,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":635892,"name":"Jason da Silva Castanheira","orcid":"0000-0002-7022-9009","position":1,"is_corresponding":false},{"id":986849,"name":"Clotilde Degroot","orcid":null,"position":2,"is_corresponding":false},{"id":343839,"name":"Edward A. Fon","orcid":"0000-0002-5520-6239","position":3,"is_corresponding":false},{"id":463576,"name":"Sylvain Baillet","orcid":"0000-0002-6762-5713","position":4,"is_corresponding":false},{"id":986850,"name":"Quebec Parkinson Network","orcid":null,"position":5,"is_corresponding":false},{"id":349842,"name":"Alex I. Wiesman","orcid":"0000-0003-0917-1570","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-19T00:31:31.270564Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}