{"doi":"10.1101/2022.08.03.502672","title":"A long interval between priming and boosting SARS-CoV-2 mRNA vaccine doses enhances B cell responses with limited impact on T cell immunity","abstract":"SUMMARY Spacing the first two doses of SARS-CoV-2 mRNA vaccines beyond 3-4 weeks raised initial concerns about vaccine efficacy. While studies have since shown that long-interval regimens induce robust antibody responses, their impact on B and T cell immunity is poorly known. Here, we compare in SARS-CoV-2 naïve donors B and T cell responses to two mRNA vaccine doses administered 3-4 versus 16 weeks apart. After boost, the longer interval results in higher magnitude and a more mature phenotype of RBD-specific B cells. While the two geographically distinct cohorts present quantitative and qualitative differences in T cell responses at baseline and after priming, the second dose led to convergent features with overall similar magnitude, phenotype and function of CD4 + and CD8 + T cell responses at post-boost memory timepoints. Therefore, compared to standard regimens, a 16-week interval has a favorable impact on the B cell compartment but minimally affects T cell immunity.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":301650,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":347020,"name":"Gérémy Sannier","orcid":"0000-0001-7956-4463","position":1,"is_corresponding":false},{"id":254285,"name":"Mathieu Dubé","orcid":"0000-0002-5522-9019","position":2,"is_corresponding":false},{"id":623260,"name":"Manon Nayrac","orcid":"0000-0001-5717-6232","position":3,"is_corresponding":false},{"id":480442,"name":"Mark M. Painter","orcid":"0000-0002-0180-2748","position":4,"is_corresponding":false},{"id":6622,"name":"Rishi Raj Goel","orcid":"0000-0003-1715-5191","position":5,"is_corresponding":false},{"id":843371,"name":"Mélanie Laporte","orcid":null,"position":6,"is_corresponding":false},{"id":243836,"name":"Halima Medjahed","orcid":null,"position":7,"is_corresponding":false},{"id":614837,"name":"Justine C. Williams","orcid":"0000-0001-8552-6447","position":8,"is_corresponding":false},{"id":347021,"name":"Nathalie Brassard","orcid":"0000-0002-4320-9416","position":9,"is_corresponding":false},{"id":254282,"name":"Julia Niessl","orcid":"0000-0001-8852-1924","position":10,"is_corresponding":false},{"id":624528,"name":"Laurie Gokool","orcid":null,"position":11,"is_corresponding":false},{"id":624529,"name":"Chantal Morrisseau","orcid":null,"position":12,"is_corresponding":false},{"id":624530,"name":"Pascale Arlotto","orcid":null,"position":13,"is_corresponding":false},{"id":17392,"name":"Cécile Tremblay","orcid":"0000-0002-3440-3436","position":14,"is_corresponding":false},{"id":623265,"name":"Valérie Martel‐Laferrière","orcid":"0000-0001-7973-8582","position":15,"is_corresponding":false},{"id":241588,"name":"Andrés Finzi","orcid":"0000-0002-4992-5288","position":16,"is_corresponding":false},{"id":105450,"name":"Allison R. Greenplate","orcid":"0000-0002-2614-3072","position":17,"is_corresponding":false},{"id":36451,"name":"E. John Wherry","orcid":"0000-0003-0477-1956","position":18,"is_corresponding":false},{"id":254288,"name":"Daniel E. Kaufmann","orcid":"0000-0003-4467-136X","position":19,"is_corresponding":false},{"id":896275,"name":"Alexandre Nicolas","orcid":"0000-0002-8953-3924","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T00:32:02.193874Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}