{"doi":"10.1101/2022.08.01.502390","title":"SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta","abstract":"Since the emergence of SARS-CoV-2, five different variants of concern (VOCs) have been identified: Alpha, Beta, Gamma, Delta, and Omicron. Due to confounding factors in the human population, such as pre-existing immunity, comparing severity of disease caused by different VOCs is challenging. Here, we investigate disease progression in the rhesus macaque model upon inoculation with the Delta, Omicron BA.1, and Omicron BA.2 VOCs. Disease severity in rhesus macaques inoculated with Omicron BA.1 or BA.2 was lower than those inoculated with Delta and resulted in significantly lower viral loads in nasal swabs, bronchial cytology brush samples, and lung tissue in rhesus macaques. Cytokines and chemokines were upregulated in nasosorption samples of Delta animals compared to Omicron BA.1 and BA.2 animals. Overall, these data suggests that in rhesus macaques, Omicron replicates to lower levels than the Delta VOC, resulting in reduced clinical disease.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":297395,"datarank":0.5504084488729564,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.19072415795320075,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.19072415795320075,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":8,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":803860,"name":"Manmeet Singh","orcid":"0000-0003-0917-8844","position":1,"is_corresponding":false},{"id":872035,"name":"Taylor A. Saturday","orcid":null,"position":2,"is_corresponding":false},{"id":108653,"name":"Claude Kwe Yinda","orcid":"0000-0002-5195-5478","position":3,"is_corresponding":false},{"id":107176,"name":"Lizzette Pérez-Pérez","orcid":"0000-0001-5881-4363","position":4,"is_corresponding":false},{"id":867702,"name":"Forrest Bohler","orcid":"0000-0002-9963-2213","position":5,"is_corresponding":false},{"id":898793,"name":"Zachary A. Weishampel","orcid":"0000-0002-5019-1875","position":6,"is_corresponding":false},{"id":662279,"name":"Matthew Lewis","orcid":"0000-0002-6657-7588","position":7,"is_corresponding":false},{"id":107172,"name":"Jonathan E. Schulz","orcid":"0000-0001-5462-5952","position":8,"is_corresponding":false},{"id":107181,"name":"Brandi N. Williamson","orcid":"0000-0002-9524-4395","position":9,"is_corresponding":false},{"id":107175,"name":"Kimberly Meade‐White","orcid":"0000-0003-0503-8174","position":10,"is_corresponding":false},{"id":926896,"name":"Shane Gallogly","orcid":"0000-0001-6161-9104","position":11,"is_corresponding":false},{"id":107174,"name":"Atsushi Okumura","orcid":"0000-0002-7779-3059","position":12,"is_corresponding":false},{"id":107169,"name":"Friederike Feldmann","orcid":"0000-0002-1363-1077","position":13,"is_corresponding":false},{"id":107189,"name":"Jamie Lovaglio","orcid":"0000-0002-7567-446X","position":14,"is_corresponding":false},{"id":107190,"name":"Patrick W. Hanley","orcid":"0000-0003-2300-1818","position":15,"is_corresponding":false},{"id":552057,"name":"Carl Shaia","orcid":"0000-0001-8907-8821","position":16,"is_corresponding":false},{"id":107426,"name":"Heinz Feldmann","orcid":"0000-0001-9448-8227","position":17,"is_corresponding":false},{"id":106696,"name":"Emmie de Wit","orcid":"0000-0002-9763-7758","position":18,"is_corresponding":false},{"id":107194,"name":"Vincent J. Munster","orcid":"0000-0002-2288-3196","position":19,"is_corresponding":false},{"id":237970,"name":"Kyle Rosenke","orcid":"0000-0001-8101-4348","position":20,"is_corresponding":false},{"id":107159,"name":"Neeltje van Doremalen","orcid":"0000-0003-4368-6359","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:26.161109Z","pmid":"35971544","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}